Anti-PEG10-抗体-抗体-生物在线
Anti-PEG10

Anti-PEG10

商家询价

产品名称: Anti-PEG10

英文名称:

产品编号: 200804

产品价格: null

产品产地: 成都正能生物

品牌商标: Zen BioScience

更新时间: null

使用范围: WB,IP

成都正能生物技术有限责任公司
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  • 地址 : 中国成都高新区科园南路爱斯特大厦
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  • 所在区域 : 四川
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Size  100ug

Cat code  200804

Species Cross-reactivity  H

Key Application  WB,IP

Host  Mouse

Antibody type  Monoclonal antibody

Purified method  Affinity purified

Isotype  IgG1

Molecular Weight  55kDa

Sensitivity  This antibody detects endogenous levels of PEG10 and does not cross-react with related proteins.

Immunogen  Purified recombinant human PEG10 protein fragments expressed in E.coli.

UniProt Number  Q86TG7

GeneBank ID  NM_001040152

Subcellular location  Nucleus. Cytoplasm

Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol

Altername  Retrotransposon-derived protein PEG10;Embryonal carcinoma differentiation-regulated protein;Mammalian retrotransposon-derived protein 2;Myelin expression factor 3-like protein 1;Paternally expressed gene 10 protein;Retrotransposon gag domain-containing protein 3;Retrotransposon-derived gag-like polyprotein;Ty3/Gypsy-like protein

Gene_symbol  EDR; HB-1; Mar2; MEF3L; Mart2; RGAG3

Summary  This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas. [provided by RefSeq, May 2010]

UniPort summary Function  Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5´-GCCTGTCTTT-3´ DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter

Application Images :  

Western blot detection of PEG10 in Hela cell lysates using PEG10 antibody (1:1000 diluted). Predicted band size:55KDa. Observed band size:55KDa,95KDa

Immunoprecipitation analysis of Hela cell lysates using PEG10 antibody