小提示:此产品厂家联系方式可能失效,请谨慎联系

推荐以下产品,您是否有兴趣......

  Anti-ZFP28/FITC Conjugated抗体  [供应商:上海钰博生物科技有限公司]
  Anti-ZFP2/ZNF751/FITC Conjugated抗体  [供应商:上海钰博生物科技有限公司]
  Anti-MCM6/FITC Conjugated抗体  [供应商:上海钰博生物科技有限公司]
  Anti-MRPS36/FITC Conjugated抗体  [供应商:上海钰博生物科技有限公司]
  Anti-MOG1/FITC Conjugated抗体  [供应商:上海钰博生物科技有限公司]
  Anti-CWF19L2/FITC Conjugated抗体  [供应商:上海钰博生物科技有限公司]
  Anti-CPNE7/FITC Conjugated抗体  [供应商:上海钰博生物科技有限公司]
  Anti-Adenovirus hexon protein/FITC Conjugated抗体  [供应商:上海钰博生物科技有限公司]
  Anti-PBX1/FITC Conjugated抗体  [供应商:上海钰博生物科技有限公司]
  Anti-LIN7C/FITC Conjugated抗体  [供应商:上海钰博生物科技有限公司]

DNA-PKcs成都正能生物技术有限责任公司

性能参数

产品名称: DNA-PKcs
抗体货号: 200618-6D1
产品规格: 100ul(WB 1:1000)
级    别: Affinity purified
产品产地: 成都正能生物
品牌商标: Zen BioScience
价    格: 3680元
抗原来源: Human
抗体来源: Mouse
适用物种: H
Isotype:IgG1
应用范围: WB,IP,ICC
更新时间: 2019/7/7 15:24:00
详细资料:  实验方法技术资料
浏览人数:894
诚信指数:121点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
点此求购
生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

成都正能生物技术有限责任公司
地址:
中国成都高新区科园南路爱斯特大厦
邮编:
610200
电话:
028-85739596
传真:
+86-028-85739596
联系人:
小能
所在区域:
四川·成都
邮件:
公司展台:
扫一扫,关注我们

产品详细描述

Size  100ug

Cat code  200618-6D1

Species Cross-reactivity  H

Key Application  WB,IP,ICC

Host  Mouse

Antibody type  Monoclonal antibody

Purified method  Affinity purified

Isotype  IgG1

Molecular Weight  450kDa

Sensitivity  This antibody detects endogenous levels of DNA-PKcs,and does not cross-react with related proteins.

Immunogen  Purified recombinant human DNA-PKcs protein fragments expressed in E.coli

UniProt Number  P78527

GeneBank ID  NM_006904

Subcellular location  Nucleus.

Formulation  Purified mouse monoclonal in PBS(pH 7.4)containing with 0.2% sodium azide,0.1%BSA & 50% glycerol.

Altername  DNA dependent protein kinase catalytic subuni;DNA PKcs;DNA-dependent protein kinase catalytic subunit;DNA-PK catalytic subunit;DNA-PKcs;DNAPK;DNPK1;hyper radiosensitivity of murine scid mutation, complementing 1;HYRC;HYRC1;p350;p460;PRKDC;PRKDC_HUMAN;protein kinase, DNA activated, catalytic polypeptide;XRCC7;

Gene_symbol  p460;scid;slip;DNAPK;DNPK1;HYRC1;XRCC7;dxnph;DOXNPH;DNAPDcs;AI326420;AU019811;DNA-PKcs

Summary  This gene encodes the catalytic subunit of the DNA-dependent protein kinase(DNA-PK).It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination.The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq,Jul 2010]

UniPort summary Function  Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage.Involved in DNA nonhomologous end joining(NHEJ)required for double-strand break(DSB)repair and V(D)J recombination.Must be bound to DNA to express its catalytic properties.Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis(DCLRE1C).The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step.Required to protect and align broken ends of DNA.May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage.Found at the ends of chromosomes,suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion.Also involved in modulation of transcription.Recognizes the substrate consensus sequence[ST]-Q.Phosphorylates´Ser-139´ of histone variant H2AX/H2AFX,thereby regulating DNA damage response mechanism.Phosphorylates DCLRE1C,c-Abl/ABL1,histone H1,HSPCA,c-jun/JUN,p53/TP53, PARP1, POU2F1,DHX9,SRF,XRCC1,XRCC1,XRCC4,XRCC5,XRCC6,WRN,MYC and RFA2.Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA.Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D.

Application Images :  

Western blot detection of PRKDC in Hela & K562 cell lysates using PRKDC antibody(1:1000 diluted).Predicted band size:450KDa,Observed band size:450KDa.

Immunocytochemistry stain of Hela using PRKDC antibody (1:100).

Immunoprecipitation analysis of Hela cell lysate using PRKDC antibody.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

查看DNA-PKcs产品的用户还对以下产品感兴趣

暂无

ADVERTISEMENT

找不到您所需的产品,发布求购试试?

标题:*
描述:
姓名:*
Email:*
单位:*
电话:*
地址:*
邮编:
资料: 需要 不需要
报价: 需要 不需要