Cat code 200287
Species Cross-reactivity H,R
Key Application WB,ICC
Antibody type Monoclonal antibody
Purified method Affinity purified
Molecular Weight 54kDa
Sensitivity This antibody detects endogenous levels of MPI and does not cross-react with related proteins.
Immunogen Purified recombinant human MPI protein fragments expressed in E.coli.
UniProt Number P34949
GeneBank ID NM_002435.1
Subcellular location Cytoplasm
Formulation Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Altername Phosphohexomutase；Phosphomannose isomerase，Short name=PMI
Gene_symbol PMI; PMI1; CDG1B
Summary Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib.
UniPort summary Function Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Application Images :
Western blot detection of MPI in Rat kidney,Rat brain，A549&LNCAP cell lysates and using MPI antibody (1:1000 diluted). Predicted band size: 54KDa Observed band size: 45KDa
Immunocytochemistry stain of Hela using MPI antibody (1:300).
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