Cat code 200457
Species Cross-reactivity H
Key Application WB
Antibody type Monoclonal antibody
Purified method null
Molecular Weight 57kDa
Sensitivity This antibody detects endogenous levels of PPP5C and does not cross-react with related prote
Immunogen Purified recombinant human PPP5C protein fragments expressed in E.coli.
UniProt Number P53041
GeneBank ID NM_006247.2
Subcellular location Nucleus. Cytoplasm.
Altername Protein phosphatase T;Protein Phosphatase 5;PPP5C
Gene_symbol PP5; PPT; PPP5
Summary This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants.
UniPort summary Function May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1.
Application Images :
Western blot detection of PPP5C in Hela，Jurkat,293T,A431&MCF7 cell lysates using PPP5C antibody (1:1000 diluted). Predicted band size: 57kDa Observed band size: 57kDa