Size  100ug
Cat code  200637
Species Cross-reactivity  H
Key Application  WB,IP
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG1
Molecular Weight  98kDa
Sensitivity  This antibody detects endogenous levels of NUP98 and does not cross-react with related proteins.
Immunogen  Purified recombinant human NUP98 protein fragments expressed in E.coli.
UniProt Number  P52948
GeneBank ID  NM_016320.3
Subcellular location  Nucleus ? nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. 
Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol
Altername  1.Nuclear pore complex protein Nup98
Alternative name(s):
98 kDa nucleoporin
Nucleoporin Nup982.Nuclear pore complex protein Nup96
Alternative name(s):
96 kDa nucleoporin
Nucleoporin Nup96
Gene_symbol  ADIR2; NUP96; NUP196 
Summary  Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. 
UniPort summary  Function  Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport.
Application Images :  
Western blot detection of NUP98 in Hela，Jurkat&MCF7 cell lysates using NUP98 antibody (1:1000 diluted).
Predicted band size: 98kDa
Observed band size: 98kDa
Immunoprecipitation analysis of Hela cell lysates using NUP98 antibody