Size  100ug
Cat code  310001
Species Cross-reactivity  H,M,Mk,R
Key Application  WB
Host  Rabbit
Antibody type  Polyclonal antibody
Purified method  Affinity purified
Isotype  
Molecular Weight  44kDa
Sensitivity  The antibody detects endogenous level of MEK2 only when phosphorylated at threonine 394.
Immunogen  Peptide sequence around phosphorylation site of threonine 394 (P-G-T(p)-P-T) derived from Human MEK-2.
UniProt Number  P36507
GeneBank ID  NM_030662.3
Subcellular location  Cytoplasm
Formulation  Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Altername  Cardiofaciocutaneous syndrome ,CFC syndrome ,Dual specificity mitogen activated protein kinase kinase 2 , Dual specificity mitogen activated protein kinase kinase 2 ,Dual specificity mitogen-activated protein kinase kinase 2 ,ERK activator kinase 2 ,ERK activator kinase 2 ,FLJ26075 ,MAP kinase kinase 2 ,MAP kinase kinase 2 ,MAP2K 2 ,MAP2K 2 ,map2k2 ,MAPK / ERK kinase 2 ,MAPK / ERK kinase 2 ,MAPK/ERK kinase 2 ,MAPKK 2 ,MAPKK 2 ,MAPKK2 ,MAPKK2 ,MEK 2 ,MEK2 ,Microtubule Associated Protein Kinase Kinase 2 ,Microtubule Associated Protein Kinase Kinase 2 ,Mitogen activated protein kinase kinase 2 ,Mitogen activated protein kinase kinase 2 p45 ,Mitogen activated protein kinase kinase 2 p45 ,MKK 2 ,MKK 2 ,MKK2 ,MKK2 ,MP2K2_HUMAN ,OTTHUMP00000165826 ,OTTHUMP00000165827 ,PRKMK 2 ,PRKMK2 ,
Gene_symbol  MEK2; MKK2; MAPKK2; PRKMK2
Summary  The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
UniPort summary  Function  Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases
Application Images :  
Western blot detection of MEK-2 antibody in C6, COS7, 3T3, Hela cell lysates using MEK-2 antibody(dilution 1:300). Predicted band size: 44KDa. Observed band size: 44KDa.