Anti-Bcl2-抗体-抗体-生物在线
Anti-Bcl2

Anti-Bcl2

商家询价

产品名称: Anti-Bcl2

英文名称:

产品编号: 310004

产品价格: null

产品产地: 成都正能生物

品牌商标: Zen BioScience

更新时间: null

使用范围: WB

成都正能生物技术有限责任公司
  • 联系人 :
  • 地址 : 中国成都高新区科园南路爱斯特大厦
  • 邮编 : 610200
  • 所在区域 : 四川
  • 电话 : 180****2350
  • 传真 : +86-028-85739596
  • 邮箱 : sales@zen-bioscience.com

Size  100ug

Cat code  310004

Species Cross-reactivity  H,Mk

Key Application  WB

Host  Rabbit

Antibody type  Polyclonal antibody

Purified method  Affinity purified

Isotype  

Molecular Weight  26kDa

Sensitivity  The antibody detects endogenous level of total BCL-2 protein.

Immunogen  Peptide sequence around aa. 54~58 (G-H-T-P-H) derived from Human BCL-2.

UniProt Number  P10415

GeneBank ID  NM_000633.2

Subcellular location  Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane;

Formulation  Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Altername  Apoptosis regulator Bcl 2 ;Apoptosis regulator Bcl-2 ;Apoptosis regulator Bcl2 ; AW986256 ;B cell CLL/lymphoma 2 ;B cell leukemia/lymphoma 2 ;B cell lymphoma 2 ;Bcl 2 ;Bcl-2 ;Bcl2 ;BCL2 protein ;BCL2_HUMAN ;C430015F12Rik ;D630044D05Rik ;D830018M01Rik ;Leukemia/lymphoma, B-cell, 2 ;Oncogene B-cell leukemia 2 ;PPP1R50 ;Protein phosphatase 1, regulatory subunit 50 .

Gene_symbol  Bcl-2; PPP1R50

Summary  This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]

UniPort summary Function  Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Application Images :  

Western blot detection of BCL2 antibody in a549, Hela and COS7 cell lysates using BCL2 antibody(dilution 1:300).Predicted band size:26 Kda.Observed band size:26KDa.