甲基化赖氨酸 (Methylated Lysine) pAb
产品名称: 甲基化赖氨酸 (Methylated Lysine) pAb
英文名称: Methylated Lysine Polyclonal Antibody
产品编号: SPC-158F
产品价格: null
产品产地: 加拿大
品牌商标: StressMarq
更新时间: null
使用范围: WB, IP, ELISA
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- 地址 : 加拿大
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- 所在区域 : 其他
- 电话 : 138****6620;
- 传真 : 123456
- 邮箱 : hedyl@stressmarq.com
Western blot analysis of Methylated Lysine in BSA (Left) and Methylated BSA (Right), using a 1:1000 dilution of SPC-158.
Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of Lysine involves methylation (1). Lysine can be methylated once, twice or three times by lysine methyltransferases. The transfer of methyl groups from S-adenosyl methionine to histones is catalyzed by enzymes known as histone methyltransferases. Histones which are methylated on certain residues can act epigenetically to repress or activate gene expression (1, 2). The transcriptional repressor SUV39H1 can encode novel enzymes which selectively methylate histone H3 at lysine 9. SUV39H1 places a methyl marker on histone H3, which is then recognized by HP1 through its chromo domain. This model may also explain the stable inheritance of the heterochromatic state (3). Some studies have also speculated a stimulatory role for transcription by methylated histone lyside 4 due to its presence at active transcription sites (4-6). 1. Yang XJ. (2005). Oncogene. 24:1653-1662. 2. Melcher M. et al. (2000). Mol Cell Biol 20: 3728– 3741. 3. Bannister AJ. et al. (2001). Nature 410(6824): 120-4. 4. Im H. et al. (2003). J Biol Chem. 278: 18346-18352. 5. Ng H.H., et al. (2002). J Biol Chem. 277: 34655-34657. 6. Zegerman P., et al. (2002). J Biol Chem. 277: 11621- 11624.
最新发表文献
1. Katzenback, B.A., Dawson, N.J., Storey, K.B. (2014). Purification and characterization of a urea sensitive lactate dehydrogenase from the liver of the African clawed frog, Xenopus laevis. J Comp Physiol B. DOI: 10.1007/s00360-014-0824-1
2. Dawson, N.J., Bell, R.A.V. and Storey, K.B. (2013). Purification and Properties of White Muscle Lactate Dehydrogenase from the Anoxia-Tolerant Turtle, the Red-Eared Slider, Trachemys scripta elegans. Enzyme Res. 2013. Article ID 784973. doi:10.1155/2013/784973
3. Shahriaria A., Dawsonb N., Bellb R., Storey, K. (2013). Stable suppression of lactate dehydrogenase activity during anoxia in the foot muscle of Littorinalittorea and the potential role of acetylation as a novel posttranslational regulatory mechanism. University of Ahvaz, Ahvaz, Iran, Carleton University, Ottawa, Canada. Link to PDF.