DNA Damage, 8-OHdG EIA kit-试剂盒-抗体-生物在线
DNA Damage, 8-OHdG EIA kit

DNA Damage, 8-OHdG EIA kit

商家询价

产品名称: DNA Damage, 8-OHdG EIA kit

英文名称: DNA Damage, 8-OHdG EIA kit

产品编号: SKT-120-96

产品价格: null

产品产地: 加拿大

品牌商标: StressMarq

更新时间: null

使用范围: EIA 样本类型 urine, cell culture, plasma and other sample matrices

StressMarq
  • 联系人 :
  • 地址 : 加拿大
  • 邮编 :
  • 所在区域 : 其他
  • 电话 : 138****6620;
  • 传真 : 123456
  • 邮箱 : hedyl@stressmarq.com

8-hydroxy-2-deoxy Guanosine (8-OHdG) is produced by the oxidative damage of DNA (see Figure 1, on page 6) by reactive oxygen and nitrogen species and serves as an established marker of oxidative stress. Hydroxylation of guanosine occurs in response to both normal metabolic processes and a variety of environmental factors (i.e., anything that increases reactive oxygen and nitrogen species). Increased levels of 8-OHdG are associated with the aging process as well as with a number of pathological conditions including cancer, diabetes, and hypertension. In complex samples such as plasma, cell lysates, and tissues, 8-OHdG can exist as either the free nucleoside or incorporated in DNA. Once the blood enters the kidney, free 8-OHdG is readily filtered into the urine, while larger DNA fragments remain in the bloodstream. Because of the complexity of plasma samples, urine is a more suitable matrix for the measurement of free 8-OHdG than plasma. Urinary levels of 8-OHdG range between 2.7-13 ng/mg creatine, while plasma levels of free 8-OHdG have been reported to be between 4-21 pg/ml as determined by LC-MS.

最新发表文献:

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7. Gehrke, N. et al. (2013) Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing. Immunity. 39(3):482-95. doi:10.1016/j.immuni.2013.08.004.

8.  Hinch, E. C. A., Sullivan-Gunn, M. J., Vaughan V. C., McGlynn M. A., Lewandowski, Paul A. (2013). Disruption of pro-oxidant and antioxidant systems with elevated expression of the ubiquitin proteosome system in the cachectic heart muscle of nude mice.  Journal of Cachexia, Sarcopenia and Muscle. doi: 10.1007/s13539-013-0116-8

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