CHRNA4,烟碱型乙酰胆碱受体α4抗体

产品编号HZ-1038R
英文名称CHRNA4
中文名称烟碱型乙酰胆碱受体α4抗体
别 名Cholinergic receptor nicotinic alpha 4; Cholinergic receptor nicotinic alpha polypeptide 4; Cholinergic receptor nicotinic alpha polypeptide 4; cholinergic receptor, nicotinic, alpha 4; cholinergic receptor, nicotinic, alpha 4 subunit precursor; ACRA4; ALPHA-4NACHR; ALPHA4 ACHR; BFNC; CHRNA4; CHRNA 4; EBN 1; EBN; EBN1; ENFL1; FLJ95812; NACHR; nAChR alpha-4; NACHRA4; NACRA4; NARAC; Nicotinic Acetylcholine Receptor alpha 4; A4 nicotinic receptor; Acetylcholine receptor alpha 4 neural; Acetylcholine receptor neuronal nicotinic alpha 4 subunit; ACH 4; ACH4; Acra 4; Acra4; Alpha4 nAChR; BFNC; Cholinergic receptor nicotinic alpha polypeptide 4; ACHA4_HUMAN; NACRA 4; NACRA4; Neuronal acetylcholine receptor subunit alpha-4; Neuronal nicotinic acetylcholine receptor alpha 4 subunit; Neuronal nicotinic acetylcholine receptor alpha 4 subunit.
说 明 书0.1ml 0.2ml
研究领域肿瘤 神经生物学 通道蛋白 细胞膜受体 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
CHRNA4,烟碱型乙酰胆碱受体α4抗体交叉反应Human, Mouse, Rat, Chicken,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量67kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CHRNA4 C-terminus
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CHRNA4,烟碱型乙酰胆碱受体α4抗体PubMedPubMed
产品介绍background:
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type1. Polymorphisms in this gene that provide protection against nicotine addiction have been described.

Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.

Subunit:
Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers. Interacts with RIC3; which is required for proper folding and assembly.

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor (By similarity).

DISEASE:
Epilepsy, nocturnal frontal lobe, 1 (ENFL1) [MIM:600513]: An autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements. Note=The disease is caused by mutations affecting the gene represented in this entry.

CHRNA4,烟碱型乙酰胆碱受体α4抗体Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily.

Gene ID:
1137

Database links:
Entrez Gene: 1137 Human
Entrez Gene: 11438 Mouse
Entrez Gene: 25590 Rat
Omim: 118504 Human
SwissProt: P43681 Human
SwissProt: O70174 Mouse
SwissProt: P09483 Rat
Unigene: 10734 Human
Unigene: 252369 Mouse
Unigene: 9697 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.