CCL1/TCA3,嗜酸粒细胞趋化蛋白CCL1前体蛋白抗体

产品编号HZ-2450R
英文名称CCL1/TCA3
中文名称嗜酸粒细胞趋化蛋白CCL1前体蛋白抗体
别 名C-C motif chemokine 1 precursor; chemokine (C-C motif) ligand 1; BF534335; I-309; Scya1; Chemokine CC Motif Ligand 1; inflammatory cytokine I-309; P500; SCYA1; SISe; small inducible cytokine A1; T lymphocyte secreted protein I-309; CCL1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Rabbit,
CCL1/TCA3,嗜酸粒细胞趋化蛋白CCL1前体蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量10kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CCL1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CCL1/TCA3,嗜酸粒细胞趋化蛋白CCL1前体蛋白抗体PubMedPubMed
产品介绍background:
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine receptor CCR8. [provided by RefSeq, Jul 2008].

Function:
Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.

Subunit:
Monomer.

Subcellular Location:
Secreted.

Similarity:
Belongs to the intercrine beta (chemokine CC) family.

Gene ID:
6346

CCL1/TCA3,嗜酸粒细胞趋化蛋白CCL1前体蛋白抗体Database links:
Entrez Gene: 6346 Human
Omim: 182281 Human
SwissProt: P22362 Human
Unigene: 72918 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CCL1属于CC趋化因子家族，是由活化的T细胞分泌的糖蛋白。CCL1是一小分子的细胞因子C与细胞表面的趋化因子受体CCR8结合,对单核细胞，自然杀伤细胞，未成熟的B细胞和树突状细胞有细胞趋化作用.

产品图片

Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-I-309/CCL1 precursor Polyclonal Antibody, Unconjugated(HZ-2450R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining