CD93,CD93抗体

产品编号HZ-2474R
英文名称CD93
中文名称CD93抗体
别 名C1qrp; Complement component C1q receptor; C1q/MBL/SPA receptor; C1qR(p); C1qr1; C1qRp; CD93 antigen; CD93 molecule; CDw93; Complement component 1 q subcomponent receptor 1; Complement component C1q receptor; dJ737E23.1; ECSM3; Ly68; Matrix remodeling associated protein 4; MXRA4.
说 明 书0.1ml 0.2ml
研究领域免疫学 细胞粘附分子 细胞表面分子 糖蛋白 细胞类型标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
CD93,CD93抗体产品应用IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量70kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CD93
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD93,CD93抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008].

Function:
Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.

Subunit:
Interacts with HCV core protein. Interacts with C1QBP; the association may represent a cell surface C1q receptor.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.

CD93,CD93抗体Post-translational modifications:
N- and O-glycosylated.

Similarity:
Contains 1 C-type lectin domain.
Contains 5 EGF-like domains.

Gene ID:
22918

Database links:
Entrez Gene: 22918 Human
Entrez Gene: 17064 Mouse
Entrez Gene: 84398 Rat
Omim: 120577 Human
SwissProt: Q9NPY3 Human
SwissProt: O89103 Mouse
SwissProt: Q9ET61 Rat
Unigene: 97199 Human
Unigene: 681 Mouse
Unigene: 162695 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.