CCL12,单核细胞趋化蛋白5抗体

产品编号HZ-2478R
英文名称CCL12
中文名称单核细胞趋化蛋白5抗体
别 名MCP5; C-C motif chemokine 12; CCL12; MCP 5; MCP-5; MCP5; Macrophage/monocyte Chemotactic Protein; OTTMUSP00000000792; Scya12; Small inducible cytokine A12.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,
CCL12,单核细胞趋化蛋白5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量9kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from mouse CCL12
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CCL12,单核细胞趋化蛋白5抗体PubMedPubMed
产品介绍background:
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.

Function:
Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.

Subunit:
Homodimer.

Subcellular Location:
Secreted.

Tissue Specificity:
Predominantly expressed in the lymph nodes and thymus. Also found in the salivary glands containing lymph nodes, breast, heart, lung, brain, small intestine, kidney and colon.

Similarity:
Belongs to the intercrine beta (chemokine CC) family.

Gene ID:
20293

CCL12,单核细胞趋化蛋白5抗体Database links:
Entrez Gene: 100862578 Mouse
Entrez Gene: 20293 Mouse
SwissProt: Q62401 Mouse
Unigene: 867 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.