CD2,CD2抗体-抗体-抗体-生物在线
CD2,CD2抗体

CD2,CD2抗体

商家询价

产品名称: CD2,CD2抗体

英文名称: Anti-CD2 antibody

产品编号: HZ-2515R

产品价格: null

产品产地: 中国/美国

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: WB,ELISA,IHC-P,IHC-F,IF

上海沪震实业有限公司
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  • 邮编 : 200612
  • 所在区域 : 上海
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CD2,CD2抗体

产品编号HZ-2515R
英文名称CD2
中文名称CD2抗体
别 名T-cell surface antigen CD2; CD 2; CD2 antigen; CD2 molecule; LFA2; LFA3 receptor; Lymphocyte function antigen 2; p50; Rosette receptor; Sheep erythrocyte receptor; Sheep red blood cell receptor; SRBC; T cell surface antigen CD2; T cell surface antigen T11/Leu 5; T11; CD2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 干细胞 细胞表面分子 糖蛋白 自然杀伤细胞 淋巴细胞 t-淋巴细胞 b-淋巴细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Horse,
CD2,CD2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量37kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CD2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD2,CD2抗体PubMedPubMed
产品介绍background:
CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes.
CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggering of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukaemias of T cell origin.

Function:
CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Subunit:
Interacts with CD2AP. Interacts with PSTPIP1.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

CD2,CD2抗体Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Gene ID:
914

Database links:
Entrez Gene: 914 Human
Entrez Gene: 12481 Mouse
Entrez Gene: 497761 Rat
Omim: 186990 Human
SwissProt: P06729 Human
SwissProt: P08920 Mouse
SwissProt: P08921 Rat
Unigene: 523500 Human
Unigene: 22842 Mouse
Unigene: 10328 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD2分子又称T11、绵羊红细胞受体(ER)、淋巴细胞功能相关抗原2(LFA-2)和Leu5,是人T淋巴细胞表面的单链糖蛋白.CD2分子是分布于胸腺细胞及所有成熟T淋巴细胞和大部分自然杀伤细胞表面的特征性分化抗原。CD2具有调节T淋巴细胞分化、成熟、激活和凋亡等功能,CD2与LFA-3之间的粘附功能对于T淋巴细胞TCR识别外来抗原与APC细胞表面MHC抗原复合物、肿瘤抗原、病毒感染靶细胞以及同种异体抗原均有重要的辅助作用。
最近研究表明,CD48和CD59也是CD2的配体,参与T细胞的粘附和细胞间的相互作用,此外,CD2可以与其它膜分子如CD44、CD45的功能有关。CD2具有对T细胞的旁路激活途径作用。

产品图片
Tissue/cell: Human lung cancer; 4% Paraformaldehyde-fixed and paraffin-embedded; 
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; 
Incubation: Anti-CD2 Polyclonal Antibody, Unconjugated(HZ-2515R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining