CDR2,小脑变性相关蛋白2抗体

产品编号HZ-6296R
英文名称CDR2
中文名称小脑变性相关蛋白2抗体
别 名CDR 2; CDR 62; CDR2; CDR2_HUMAN; CDR62; Cerebellar degeneration related protein 2; Cerebellar degeneration related protein; Cerebellar degeneration-related protein 2; Major Yo paraneoplastic antigen; Paraneoplastic cerebellar degeneration associated antigen; Paraneoplastic cerebellar degeneration-associated antigen; PCD 17; PCD17; Yo antibody; Yo paraneoplastic antigen.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 肿瘤细胞生物标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse,
CDR2,小脑变性相关蛋白2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量52kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CDR2/PCD17
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CDR2,小脑变性相关蛋白2抗体PubMedPubMed
产品介绍background:
CDR2 (cerebellar degeneration-related protein 2), also referred to as Yo or CDR62, is a 545 amino acid protein that is associated with the development of paraneoplastic cerebellar degeneration (PCD). PCD, an immune-mediated syndrome, belongs to a heterogeneous group of rare paraneoplastic neurologic disorders affecting the neurological system. PCD is characterized by subacute cerebellar ataxia and occurs mainly in patients with ovarian, uterine, fallopian tube or breast cancer. Patients with ovarian or breast cancer develop an immune response against cancer cell-expressed CDR2 and Purkinje neuron-expressed CDR2. The presence of the anti-CDR2 antibody in patients with PCD symptoms warrants an aggressive approach to diagnosis and treatment of the underlying cancer.

Similarity:
Belongs to the CDR2 family.

Gene ID:
1039

Database links:
Entrez Gene: 1039 Human
Entrez Gene: 12585 Mouse
Entrez Gene: 308958 Rat
Omim: 117340 Human
SwissProt: Q01850 Human
SwissProt: P97817 Mouse
Unigene: 513430 Human
Unigene: 1640 Mouse
Unigene: 3537 Rat

CDR2,小脑变性相关蛋白2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.