G protein alpha,G蛋白α抗体G蛋白α抗体上海沪震实业有限公司

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产品名称: G protein alpha,G蛋白α抗体G蛋白α抗体
英文名称: Anti-G protein alpha antibody
抗体货号: HZ-8160R
产品规格: 0.1ml/0.2ml支
级    别: , , , , 分析纯, affinit
产品产地: 中国/美国
品牌商标: HZbscience
价    格: 询价
抗原: 多肽合成
抗原来源: Rabbit
抗体来源: 见说明书
适用物种: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep
见说明书conjugate:见说明书
Isotype:IgG
应用范围: WB,ELISA,IHC-P,IHC-F,IF
更新时间: 2016-10-19 16:21:00
详细资料:  实验方法技术资料
浏览人数:21
诚信指数:305点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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产品详细描述

G protein alpha,G蛋白α抗体G蛋白α抗体

产品编号HZ-8160R
英文名称G protein alpha
中文名称G蛋白α抗体
别 名Adenylate cyclase stimulating G alpha protein; Guanine nucleotide binding protein G(s) alpha subunit; GNAS1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
G protein alpha,G蛋白α抗体G蛋白α抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量111kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human G protein alpha
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
G protein alpha,G蛋白α抗体G蛋白α抗体PubMedPubMed
产品介绍background:
GTP-binding proteins (G-proteins)are a family of heterotrimeric proteins that play a critical role in signal transduction by coupling cell surface, 7-transmembrane domain receptors to intracellular signaling pathways including second messenger generation (such as cyclic AMP, calcium and diacylglycerol), protein phosphorylation, ion channel activation, gene induction, cell growth and differentiation. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit.

Function:
Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems. The G(s) protein is involved in hormonalregulation of adenylate cyclase: it activates the cyclase inresponse to beta-adrenergic stimuli. XLas isoforms interact withthe same set of receptors as Gnas isoforms (By similarity).

Subunit:
G proteins are composed of 3 units; alpha, beta andgamma. The alpha chain contains the guanine nucleotide bindingsite. Interacts through its N-terminal region with ALEX which isproduced from the same locus in a different open reading frame.This interaction may inhibit its adenylyl cyclase-stimulatingactivity (By similarity).

Subcellular Location:
Cell membrane; Peripheral membrane protein(By similarity).

DISEASE:
Defects in GNAS are the cause of GNAS hyperfunction(GNASHYP) [MIM:139320]. This condition is characterized byincreased trauma-related bleeding tendency, prolonged bleedingtime, brachydactyly and mental retardation. Both the XLas isoformsand the ALEX protein are mutated which strongly reduces theinteraction between them and this may allow unimpeded activation ofthe XLas isoforms.
Defects in GNAS are a cause of ACTH-independentmacronodular adrenal hyperplasia (AIMAH) [MIM:219080]; also knownas adrenal Cushing syndrome due to AIMAH. A rare adrenal defectcharacterized by multiple, bilateral, non-pigmented, benign,adrenocortical nodules. It results in excessive production ofcortisol leading to ACTH-independent Cushing syndrome. Clinicalmanifestations of Cushing syndrome include facial and trunkalobesity, abdominal striae, muscular weakness, osteoporosis,arterial hypertension, diabetes.
Genetic variations in GNAS are the cause ofpseudohypoparathyroidism type 1B (PHP1B) [MIM:603233]. PHP1B ischaracterized by parathyroid hormone (PTH)-resistant hypocalcemiaand hyperphosphatemia. Patients affected with PHP1B have normalactivity of the product of GNAS, lack developmental defectscharacteristic of AHO, and typically show no other endocrineabnormalities besides resistance to PTH. Note=Most affectedindividuals have defects in methylation of the gene. In some casesmicrodeletions involving the STX16 appear to cause loss ofmethylation at exon A/B of GNAS, resulting in PHP1B. Paternaluniparental isodisomy have also been observed.
Defects in GNAS are the cause of pseudohypoparathyroidismtype 1C (PHP1C) [MIM:612462]. It is a disorder characterized byend-organ resistance to parathyroid hormone, hypocalcemia andhyperphosphatemia. It is commonly associated with Albrighthereditary osteodystrophy whose features are short stature,obesity, round facies, short metacarpals and ectopic calcification.

G protein alpha,G蛋白α抗体G蛋白α抗体Similarity:
Belongs to the G-alpha family. G(s) subfamily.

Database links:
UniProtKB/Swiss-Prot: Q5JWF2.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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