GERP,环指蛋白27抗体

产品编号HZ-9432R
英文名称GERP
中文名称环指蛋白27抗体
别 名RNF27; Lioblastoma expressed ring finger protein; Ring finger protein 27; RNF27; RP11-47A8.4; TRIM8; Tripartite motif containing 8; Tripartite motif protein TRIM8; TRIM8_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 锌指蛋白 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Horse, Sheep,
GERP,环指蛋白27抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量61kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human GERP/TRIM8/RNF27
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
GERP,环指蛋白27抗体PubMedPubMed
产品介绍background:
The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM8 (tripartite motif containing 8), also known as GERP (glioblastoma-expressed RING finger protein) or RNF27 (RING finger protein 27), is a 551 amino acid protein that is thought to function as an E3 ubiquitin-protein ligase that promotes SOCS-1 proteasomal degradation. As a widely expressed homodimer, TRIM8 localizes to nuclear bodies and contains two B box-type zinc fingers and one RING-type zinc finger. TRIM8 is expressed in lung, heart, brain and skeletal muscle, with low levels detected in intestine, placenta, leukocytes and liver. The gene encoding TRIM8 maps to human chromosome 10q24.32.

Function:
Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1 (By similarity).

Subunit:
Homodimer. Interacts with SOCS1 (via) SH2 domain and SOCS box (By similarity).

Tissue Specificity:
Widely expressed.

Similarity:
Belongs to the TRIM/RBCC family.
Contains 2 B box-type zinc fingers.
Contains 1 RING-type zinc finger.

Gene ID:
81603

GERP,环指蛋白27抗体Database links:
Entrez Gene: 81603 Human
Entrez Gene: 93679 Mouse
Entrez Gene: 688785 Rat
Omim: 606125 Human
SwissProt: Q9BZR9 Human
SwissProt: Q99PJ2 Mouse
Unigene: 336810 Human
Unigene: 392177 Mouse
Unigene: 481672 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.