SPP24,分泌性磷蛋白24抗体

产品编号HZ-8518R
英文名称SPP24
中文名称分泌性磷蛋白24抗体
别 名Secreted phosphoprotein 24; Spp-24; Secreted phosphoprotein 2; SPP2; SPP-2; SPP 2; SPP24_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human,
SPP24,分泌性磷蛋白24抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量16/21kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SPP24/SPP2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
SPP24,分泌性磷蛋白24抗体PubMedPubMed
产品介绍background:
SPP24, also known as secreted phosphoprotein 2, is a 211 amino acid secreted protein that belongs to the cystatin superfamily. Expressed in liver and plasma, SPP24 may play a role in coordinating an aspect of bone turnover. The gene that encodes SPP24 maps to human chromosome 2, which consists of 237 million bases encoding over 1,400 genes, making up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr鰉 syndrome is due to mutations in the ALMS1 gene. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes seen in modern form today in apes.

Subcellular Location:
Secreted.

Tissue Specificity:
Detected in liver and plasma.

Similarity:
Belongs to the SPP2 family.

Database links:
UniProtKB/Swiss-Prot: Q13103.1

SPP24,分泌性磷蛋白24抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.