Recombinant Human Interleukin-1 alpha上海信裕生物科技有限公司

性能参数

产品名称: Recombinant Human Interleukin-1 alpha
英文名称: Lymphocyte-activating factor, LAF, Leukocyte Endogenous Mediator, LEM, Endogenous Pyrogen, EP, Mononuclear Cell Factor, MCF, Hematopoietin-1
抗体货号: IC-101-01A
产品规格: 5μg/100μg/1mg
级    别: , 分析纯, 分析纯,
产品产地: 美国
品牌商标: XY-Bioscience
价    格: 600-28500元
抗原: 详见说明书
抗原来源: 详见说明书
抗体来源: 详见说明书
适用物种: 详见说明书
详见说明书conjugate:详见说明书
Isotype:详见说明书
应用范围: > 98 % by SDS-PAGE and HPLC analyses.
更新时间: 2018/4/25 14:13:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

上海信裕生物科技有限公司
地址:
上海市闵行莘庄工业区春东路508号A1-2F
邮编:
200612
电话:
021-60345312
传真:
021-37680378
联系人:
余琪
所在区域:
上海·上海
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产品详细描述

 Recombinant Human Interleukin-1 alpha

Synonyms Lymphocyte-activating factor, LAF, Leukocyte Endogenous Mediator, LEM, Endogenous Pyrogen, EP, Mononuclear Cell Factor, MCF, Hematopoietin-1
Species
Accession P01583
GeneID 3552
Source Escherichia coli.
Molecular Weight Approximately 18.0 kDa, a single non-glycosylated polypeptide chain containing 159 amino acids.
Quantity 5µg/100µg/1mg
AA Sequence SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
Purity > 98 % by SDS-PAGE and HPLC analyses.
Biological Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 1.0 pg/ml, corresponding to a specific activity of > 1.0 × 109 IU/mg.
Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation Lyophilized from a 0.2 µm filtered concentrated solution in 25 mM Tris-HCl, pH8.0.
Endotoxin Less than 0.01 EU/µg of rHuIL-1α GMP as determined by LAL method.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
3 months, -20 to -70 °C under sterile conditions after reconstitution.
Usage This GMP product can be for research use or further manufacturing use.
Quality statement The manufacture and testing of this product is in compliance with ICH Q7a guidelines.
Reference 1. Bankers-Fulbright, J.L., K.R. Kalli, and D.J. McKean. 1996. Life Sci, 59: 61-83.
2. Dinarello, C.A. 1997. Semin Oncol, 24: S9-81-S9-93.
Background Interleukin-1 alpha (IL-1α) is a non-secreted proinflammatory cytokine produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. Both IL-1α and IL-1β binds to the same receptor and has similar identical biological properties. Among various species, the amino acid sequence of mature IL-1α is conserved 60 % to 70 % and human IL-1 has been found to be biologically active on murine cell lines. IL-1α recently started to find effective application in cosmetic and dermatological formulations, which allow to significantly harmonizing derma architecture

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