Recombinant Human Interleukin-2上海信裕生物科技有限公司

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产品名称: Recombinant Human Interleukin-2
英文名称: IL2, T-cell Growth Factor, TCGF, Aldesleukin
抗体货号: IC-101-02
产品规格: 5μg/100μg/1mg
级    别: , 分析纯, 分析纯,
产品产地: 美国
品牌商标: XY-Bioscience
价    格: 600-28500元
抗原: 详见说明书
抗原来源: 详见说明书
抗体来源: 详见说明书
适用物种: 详见说明书
详见说明书conjugate:详见说明书
Isotype:详见说明书
应用范围: > 98 % by SDS-PAGE and HPLC analyses.
更新时间: 2018/8/15 15:44:00
详细资料:  实验方法技术资料
浏览人数:180
诚信指数:1895点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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上海信裕生物科技有限公司
地址:
上海市闵行莘庄工业区春东路508号A1-2F
邮编:
200612
电话:
021-60345312
传真:
021-37680378
联系人:
余琪
所在区域:
上海·上海
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产品详细描述

 Recombinant Human Interleukin-2

Synonyms IL2, T-cell Growth Factor, TCGF, Aldesleukin
Accession P60568
GeneID 3558
Source Escherichia coli.
Molecular Weight Approximately 15.4 kDa, a single non-glycosylated polypeptide chain containing 133 amino acids.
Quantity 5µg/100µg/1mg
AA Sequence APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS TLT
Purity > 98 % by SDS-PAGE and HPLC analyses.
Biological Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 0.1 ng/ml, corresponding to a specific activity of > 1.0 × 107 IU/mg.
Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation Lyophilized from a 0.2 µm filtered concentrated solution in 20 mM PB, pH 4.0.
Endotoxin Less than 0.01 EU/µg of rHuIL-2 GMP as determined by LAL method.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled H2O to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. Do not reconstitute in cell culture media directly.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Usage This GMP product can be for research use or further manufacturing use.
Quality statement The manufacture and testing of this product is in compliance with ICH Q7a guidelines.
Reference 1. Ma, A., R. Koka, and P. Burkett. 2006. Annu Rev Immunol, 24: 657-79.
2. Taniguchi, T., H. Matsui, T. Fujita, et al. 1983. Nature, 302: 305-10.
3. Liparoto, S.F., D.G. Myszka, Z. Wu, et al. 2002. Biochemistry, 41: 2543-51.
4. Bodnar, A., E. Nizsaloczki, G. Mocsar, et al. 2008. Immunol Lett, 116: 117-25.
5. Mosmann, T.R., T. Yokota, R. Kastelein, et al. 1987. J Immunol, 138: 1813-6.
Background IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. The receptor for IL-2 consists of three subunits (55 kDa IL2Rα, 75 kDa IL2Rβ, 64 kDa common gamma chain γc/IL2Rγ) that are present on the cell surface in varying preformed complexes. Mature human IL-2 shares 56 % and 66 % amino acid sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit cross-species activity

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