磷酸化形态发生紊乱关联激活因子1抗体上海沪震实业有限公司

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产品名称: 磷酸化形态发生紊乱关联激活因子1抗体
英文名称: phospho-DAAM1 (Thr361)
抗体货号: hz-5303R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500
更新时间: 2018/9/12 13:15:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
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上海·中国-上海
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产品详细描述

 Rabbit Anti-phospho-DAAM1 (Thr361) antibody 

 

产品编号 hz-5303R
英文名称 phospho-DAAM1 (Thr361)
中文名称 ***酸化形态发生紊乱关联激活因子1抗体
别    名 DAAM 1; DAAM-1; Dishevelled associated activator of morphogenesis 1; FLJ41657; KIAA0666.  
   
产品类型 ***酸化抗体 
研究领域 肿瘤  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, Guinea Pig, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 120-130kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human DAAM1 around the phosphorylation site of Thr361 [SA(p-T)QM]:SA(p-T)QM 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
DAAM1 (Dishevelled associated activator of morphogenesis 1) is a diaphanous-related formin which binds to dishevelled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex assembly. It is an essential component of noncanonical Wnt signaling. DAAM1 also communicates with Rho GTPases, CIP4 and Src in the regulation of the signalling pathways that co-ordinate the dynamics of the actin filament system. DAAM1 may be a coordinator of endocytosis and cytoskeletal remodeling.

Function:
Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments.

Subunit:
Homodimer. Interacts with CIP4, FNBP1 and FNBP1L. Interacts with the SH3 domains of Abl, BTK, endophilin, spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA. 

Subcellular Location:
Cytoplasm. Note=Perinuclear.

Tissue Specificity:
Expressed in all tissues examined.

Similarity:
Belongs to the formin homology family. 
Contains 1 DAD (diaphanous autoregulatory) domain. 
Contains 1 FH1 (formin homology 1) domain. 
Contains 1 FH2 (formin homology 2) domain. 
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. 

SWISS:
Q9Y4D1

Gene ID:
23002

Database links:

Entrez Gene: 23002 Human

Entrez Gene: 208846 Mouse

Omim: 606626 Human

SwissProt: Q9Y4D1 Human

SwissProt: Q8BPM0 Mouse

Unigene: 654934 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

DAAM1是蓬乱蛋白相关形态形成活化因子1或称形态发生紊乱关联激活因子1,为形成素蛋白家族的成员。Daam1是WNT/PCP通路的组成因子之一,参与细胞的内吞功能,可调节细胞骨架的形成与构建.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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