磷酸化真核翻译起始因子4B抗体上海沪震实业有限公司

性能参数

产品名称: 磷酸化真核翻译起始因子4B抗体
英文名称: phospho-EIF4B (Ser504)
抗体货号: hz-5346R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500
更新时间: 2018/5/11 14:38:00
详细资料:  实验方法技术资料
浏览人数:10
诚信指数:790点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-phospho-EIF4B (Ser504) antibody

 

产品编号 hz-5346R
英文名称 phospho-EIF4B (Ser504)
中文名称 ***酸化真核翻译起始因子4B抗体
别    名 EIF 4B; EIF-4B; Eukaryotic initiation factor 4B; IF4B_HUMAN.  
   
产品类型 ***酸化抗体 
研究领域 肿瘤  免疫学  细胞凋亡  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Dog, Cow, Horse, Rabbit, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 69kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human EIF4B around the phosphorylation site of Ser504:QQ(p-S)PT 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
eIF4B is required for the binding of mRNA to ribosomes. It functions in close association with eIF4F and eIF4A. It binds near the 5'-terminal cap of mRNA in the presence of eIF4F and ATP. It promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both eIF4A and eIF4F (referenced from swissprot).

Function:
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Subunit:
Self-associates and interacts with EIF3 p170 subunit. 

Post-translational modifications:
Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex. 

Similarity:
Contains 1 RRM (RNA recognition motif) domain.

SWISS:
P23588

Gene ID:
1975

Database links:

Entrez Gene: 1975 Human

Entrez Gene: 75705 Mouse

Entrez Gene: 300253 Rat

Omim: 603928 Human

SwissProt: P23588 Human

SwissProt: Q8BGD9 Mouse

Unigene: 648394 Human

Unigene: 702041 Human

Unigene: 290022 Mouse

Unigene: 391795 Mouse

Unigene: 95954 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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