磷酸化高迁移率核小体结合蛋白1上海沪震实业有限公司

性能参数

产品名称: 磷酸化高迁移率核小体结合蛋白1
英文名称: phospho-HMG14(Ser20+Ser24)
抗体货号: hz-5384R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500
更新时间: 2018/4/12 16:04:00
详细资料:  实验方法技术资料
浏览人数:19
诚信指数:790点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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上海·中国-上海
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产品详细描述

 Rabbit Anti-phospho-HMG14(Ser20+Ser24) antibody

 

产品编号 hz-5384R
英文名称 phospho-HMG14(Ser20+Ser24)
中文名称 ***酸化高迁移率核小体结合蛋白1
别    名 HMG14 (phospho S20 + S24); High mobility group (nonhistone chromosomal) protein 14; High mobility group nucleosome binding 1; High mobility group nucleosome binding domain containing protein 1; High mobility group protein 14; High-mobility group nucleosome binding domain 1; HMG14; HMGN 1; HMGN1; MGC104230; MGC117425; Nonhistone chromosomal protein HMG-14; Nonhistone chromosomal protein HMG14; FLJ27265; FLJ31471.  
   
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  免疫学  染色质和核信号  神经生物学  信号转导  细胞周期蛋白  结合蛋白  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 11kDa
细胞定位 细胞核 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from mouse HMGN1 around the phosphorylation site of Ser20+Ser24:RR(p-S)ARL(p-S)AK 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
Chromosomal protein HMG14 binds to the inner side of the nucleosomal DNA, thus altering the interaction between the DNA and the histone octamer and is involved in the process that maintains transcribable genes in an appropriate chromatin conformation. HMG14 has been implicated as a contributing factor in the etiology of Down syndrome.

Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.

Subcellular Location:
Nucleus. Cytoplasm. Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.

Post-translational modifications:
Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.

Similarity:
Belongs to the HMGN family.

SWISS:
P18608

Gene ID:
15312

Database links:

Entrez Gene: 614915 Cow

Entrez Gene: 3150 Human

Entrez Gene: 100044391 Mouse

Entrez Gene: 15312 Mouse

Omim: 163920 Human

SwissProt: P02316 Cow

SwissProt: P05114 Human

SwissProt: P18608 Mouse

Unigene: 87121 Cow

Unigene: 356285 Human

Unigene: 702472 Human

Unigene: 2756 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

HMGN1是一个核仁结合蛋白, 属于核小体结合高速迁移蛋白家族(A family of High Mobility Group Proteins that bind to Nucleosomesn, HMGN)含量蛋白较高,能稳定染色质的二级结构, 修复紫外线诱导的染色质DNA损伤. HMGN1的缺失可导致细胞增殖和生长发生紊乱, 通过打乱细胞的生长控制机制使一些致癌因素更为敏感并发生恶性转化. 研究表明, HMGN1在细胞核内是动态表达的,与细胞的新陈代谢有关. HMGN1蛋白和核仁的相互作用可改变染色质的结构, 并且能调节各种与DNA相关的包括转录的细胞核作用

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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