磷酸化活化蛋白激酶B抗体上海沪震实业有限公司

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产品名称: 磷酸化活化蛋白激酶B抗体
英文名称: phospho-JunB (Ser259)
抗体货号: hz-5464R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500
更新时间: 2018/8/13 13:42:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-phospho-JunB (Ser259) antibody

 

产品编号 hz-5464R
英文名称 phospho-JunB (Ser259)
中文名称 ***酸化活化蛋白激酶B抗体
别    名 JunB (phospho S259); JunB (phospho S259); p-JunB (phospho S259); JunB (phospho-Ser259); JunB (phospho Ser259); JunB (phospho-S259); p-JunB (Ser259); p-JunB (S259); Transcription factor jun-B; AP 1; AP1; Jun B; Jun B proto oncogene; Jun B protooncogene; JunB proto oncogene; JunB protoncogene 9; JunB protooncogene; Transcription factor jun B; Transcription factor junB; JUNB_HUMAN.  
   
产品类型 ***酸化抗体 
研究领域 肿瘤  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human JunB around the phosphorylation site of Ser259 [PV(p-S)PI]:PV(p-S)PI 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
The cJun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus vjun oncogene. JunB and JunD have been shown to be almost identical to cJun in their C terminal regions, which are involved in dimerization and DNA binding, whereas their N terminal domains, which are involved in transcriptional activation, diverge. JunB is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Function:
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Subunit:
Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains).

Subcellular Location:
Nucleus.

Post-translational modifications:
Ubiquitinated by ITCH, leading to its degradation.

Similarity:
Belongs to the bZIP family. Jun subfamily.
Contains 1 bZIP (basic-leucine zipper) domain.

SWISS:
P17275

Gene ID:
3726

Database links:

Entrez Gene: 3726 Human

Entrez Gene: 16477 Mouse

Entrez Gene: 24517 Rat

Omim: 165161 Human

SwissProt: P17275 Human

SwissProt: P09450 Mouse

SwissProt: P24898 Rat

Unigene: 25292 Human

Unigene: 1167 Mouse

Unigene: 470093 Mouse

Unigene: 15806 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

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