Rabbit Anti-phospho-JunB (Ser259) antibody
|别 名||JunB (phospho S259); JunB (phospho S259); p-JunB (phospho S259); JunB (phospho-Ser259); JunB (phospho Ser259); JunB (phospho-S259); p-JunB (Ser259); p-JunB (S259); Transcription factor jun-B; AP 1; AP1; Jun B; Jun B proto oncogene; Jun B protooncogene; JunB proto oncogene; JunB protoncogene 9; JunB protooncogene; Transcription factor jun B; Transcription factor junB; JUNB_HUMAN.|
|研究领域||肿瘤 转录调节因子 激酶和***酸酶|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig,|
|产品应用||WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||38kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated Synthesised phosphopeptide derived from human JunB around the phosphorylation site of Ser259 [PV(p-S)PI]:PV(p-S)PI|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The cJun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus vjun oncogene. JunB and JunD have been shown to be almost identical to cJun in their C terminal regions, which are involved in dimerization and DNA binding, whereas their N terminal domains, which are involved in transcriptional activation, diverge. JunB is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.
Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains).
Ubiquitinated by ITCH, leading to its degradation.
Belongs to the bZIP family. Jun subfamily.
Contains 1 bZIP (basic-leucine zipper) domain.
Entrez Gene: 3726 Human
Entrez Gene: 16477 Mouse
Entrez Gene: 24517 Rat
Omim: 165161 Human
SwissProt: P17275 Human
SwissProt: P09450 Mouse
SwissProt: P24898 Rat
Unigene: 25292 Human
Unigene: 1167 Mouse
Unigene: 470093 Mouse
Unigene: 15806 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications