Rabbit Anti-phospho-PTPN7 (Ser93) antibody
|别 名||PTPN7(phospho S93); BPTP 4; BPTP4; Dual specificity phosphatase 1; Hematopoietic protein tyrosine phosphatase; LC PTP; LCPTP; LPTP; Protein tyrosine phoshatase non receptor type stress induced; Protein tyrosine phoshatase nonreceptor type stress induced; Protein tyrosine phosphatase LC PTP; Protein tyrosine phosphatase non receptor type 7; PTPN 7; PTPNI; Tyrosine protein phosphatase non receptor type 7; PTN7_HUMAN.|
|研究领域||肿瘤 免疫学 信号转导 激酶和***酸酶|
|交叉反应||Human, Mouse, Rat, Cow,|
|产品应用||WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||40kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated Synthesised phosphopeptide derived from human PTPN7 around the phosphorylation site of Ser93:VR(p-S)LG|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
Monomer. Interacts with MAPK1, MAPK3 and several other MAP kinases.
Expressed exclusively in thymus and spleen.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Contains 1 tyrosine-protein phosphatase domain.
Entrez Gene: 5778 Human
Entrez Gene: 320139 Mouse
Entrez Gene: 246781 Rat
Omim: 176889 Human
SwissProt: P35236 Human
SwissProt: Q8BUM3 Mouse
SwissProt: P49445 Rat
Unigene: 402773 Human
Unigene: 258388 Mouse
Unigene: 10160 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.