Rabbit Anti-phospho-STAT6 (Thr645) antibody
|别 名||STAT6 (phospho T645); p-STAT6 (phospho T645); STAT6 (Phospho-Thr645); STAT6(phospho T645); D12S1644 IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT.|
|研究领域||免疫学 神经生物学 信号转导|
|产品应用||WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||94kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated Synthesised phosphopeptide derived from human STAT6 around the phosphorylation site of tyrosine Thr645:ST(p-T)IK|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Also known as: signal transducers and activators of transduction 6; D12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT.
Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Tyrosine phosphorylated following stimulation by IL-4 and IL-3.
Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.
Entrez Gene: 6778 Human
Entrez Gene: 20852 Mouse
Entrez Gene: 362896 Rat
Omim: 601512 Human
SwissProt: P42226 Human
SwissProt: P52633 Mouse
Unigene: 524518 Human
Unigene: 121721 Mouse
Unigene: 6880 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications