磷酸化转录因子SOX9蛋白抗体上海沪震实业有限公司

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性能参数

产品名称: 磷酸化转录因子SOX9蛋白抗体
英文名称: phospho-SOX9(Ser181)
抗体货号: hz-5641R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-50
更新时间: 2018/9/15 10:25:00
详细资料:  实验方法技术资料
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诚信指数:1030点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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上海·中国-上海
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产品详细描述

 

产品编号 hz-5641R
英文名称 phospho-SOX9(Ser181)
中文名称 ***酸化转录因子SOX9蛋白抗体
别    名 SOX9 (phospho S181); p-SOX9 (phospho S181); SOX9(phospho S181); CMD 1; CMD1; CMPD 1; CMPD1; SOX 9; Sox9; SOX9_HUMAN; SRA 1; SRA1 antibody SRY (sex determining region Y) box 9 (campomelic dysplasia autosomal; SRY (sex determining region Y) box 9; SRY (sex determining region Y)-box 9; SRY (sex-determining region Y)-box 9 protein; Transcription factor SOX 9; Transcription factor SOX-9; transcription factor SOX9; campomelic dysplasia autosomal sex reversal.  
   
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  免疫学  发育生物学  信号转导  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 60kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human SOX9 around the phosphorylation site of Ser181:RK(p-S)VK 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.

Function:
Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.

Subcellular Location:
Nucleus (Potential).

DISEASE:
Defects in SOX9 are the cause of campomelic dysplasia (CMD1) [MIM:114290]. CMD1 is a rare, often lethal, dominantly inherited, congenital osteochondrodysplasia, associated with male-to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones, unusually small scapulae, deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate, micrognatia, flat face and hypertelorism are common. Various defects of the ear are often evident, affecting the cochlea, malleus incus, stapes and tympanum. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage. 
Defects in SOX9 are the cause of 46,XX sex reversal type 2 (SRXX2) [MIM:278850]. SRXX2 is a condition in which male gonads develop in a genetic female (female to male sex reversal).

Similarity:
Contains 1 HMG box DNA-binding domain.

Gene ID:
6662

Database links:

Entrez Gene: 374148 Chicken

Entrez Gene: 6662 Human

Entrez Gene: 20682 Mouse

Entrez Gene: 140586 Rat

Omim: 608160 Human

SwissProt: P48434 Chicken

SwissProt: P48436 Human

SwissProt: Q04887 Mouse

Unigene: 647409 Human

Unigene: 286407 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

Sox9是软骨形成过程中一个十分关键的转录因子,虽然已经有研究表明骨形成蛋白2(bone morphogenetic protein 2,BMP2)能诱导Sox9的表达。
有学者认为;Sox9蛋白很可能与椎间盘退变有着密切的关系,Sox9是胶原蛋白合成过程中的一个重要的转录因子,且在软骨的发育、成熟过程中对胶原蛋白有着正向调控作用,Sox9蛋白在男性性腺调节睾丸发育中也有一定的作用

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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