Rabbit Anti-phospho-RGS19(Tyr143) antibody
|别 名||RGS19(phospho Y143); RGS19(phospho Ser143); G alpha interacting protein; GAIP; GNAI3IP; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein; Regulator of G protein signalling 19; RGSGAIP; RGS19_HUMAN; Regulator of G-protein signaling 19; RGS19; G-alpha-interacting protein.|
|研究领域||肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子|
|交叉反应||Human, Mouse, Rat, Chicken, Dog, Cow, Sheep, chk, shp, dog, hrs, cow|
|产品应用||WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||25kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated Synthesised phosphopeptide derived from human RGS19 around the phosphorylation site of Tyr143 [LI(p-Y)ED]:LI(p-Y)ED|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase activating protein that functions to down regulate Galpha i/Galpha q linked signaling.
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Interacts with GIPC PDZ domain.
Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
Fatty acylated. Heavily palmitoylated in the cysteine string motif.
Phosphorylated, mainly on serine residues.
Contains 1 RGS domain.
Entrez Gene: 10287 Human
Entrez Gene: 56470 Mouse
Entrez Gene: 59293 Rat
Omim: 605071 Human
SwissProt: P49795 Human
SwissProt: Q9CX84 Mouse
SwissProt: O70521 Rat
Unigene: 422336 Human
Unigene: 274366 Mouse
Unigene: 88166 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.