磷酸化生肌决定因子Myf5抗体-抗体-抗体-生物在线
磷酸化生肌决定因子Myf5抗体

磷酸化生肌决定因子Myf5抗体

商家询价

产品名称: 磷酸化生肌决定因子Myf5抗体

英文名称: phospho-MYF5 (phospho Ser49)

产品编号: hz-8200R

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200

上海沪震实业有限公司
  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 139****0749
  • 传真 : 021-60345367
  • 邮箱 : www.shzbio.net

 Rabbit Anti-phospho-MYF5 (phospho Ser49) antibody

 

产品编号 hz-8200R
英文名称 phospho-MYF5 (phospho Ser49)
中文名称 磷酸化生肌决定因子Myf5抗体
别    名 Myf5 (phospho S49); Myf5 (phospho Ser49); p-Myf5(phospho S49); p-Myf5(phospho Ser49); Myf-5 bHLHc2; Class C basic helix loop helix protein 2; Class C basic helix-loop-helix protein 2; Myf 5; Myf-5; Myf5; MYF5_HUMAN; Myogenic factor 5.  
   
产品类型 磷酸化抗体 
研究领域 细胞生物  免疫学  发育生物学  信号转导  干细胞  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Horse, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human MYF5 around the phosphorylation site of Ser49:LQG(p-S)D 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development include Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Of interest, most muscle cells express either Myo D or Myf-5 in the committed state, but when induced to differentiate, all turn on expression of myogenin. Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes.

Function:
Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. 

Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. 

Subcellular Location:
Nucleus.

Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.

SWISS:
P13349

Gene ID:
4617

Database links:

Entrez Gene: 4617 Human

Entrez Gene: 17877 Mouse

Entrez Gene: 299766 Rat

Omim: 159990 Human

SwissProt: P13349 Human

SwissProt: P24699 Mouse

Unigene: 178023 Human

Unigene: 4984 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

yf5是MyoD基因家族的一员,该家族的共同结构特点是具有1个保守的中央蛋白基序(motif),大小为80个氨基酸,称为碱性螺旋-环-螺旋(bHLH),bHLH高度保守,其中Basic结构是HLH螺旋结构的延伸,也是这一家族蛋白与DNA相互作用的区域,而HLH螺旋结构则是与其他因子相互作用的位点,即调控的重要区域。
生肌决定因子(MyoD)基因家族控制着肌细胞的增殖和分化,与肌纤维的数量、大小有着密切的关系,因而对肉质和风味有非常重要的作用,MyoD基因家族可编码4种不同的转录因子,分别为MyoD(Myf3)、Myogenin(MyoG)、Myf5、Myf6或MRF4,它们各自或协同控制着骨骼肌生成方面的关键调节因子