Rabbit Anti-phospho-Stathmin 1 (Ser24) antibody
|英文名称||phospho-Stathmin 1 (Ser24)|
|别 名||Stathmin 1 (phospho S24); p-Stathmin 1 (phospho S24); Stathmin 1 (Phospho-Ser24); Stathmin (Phospho Ser24); Stathmin (Phospho S24); Lag; LAP 18; LAP18; Leukemia associated phosphoprotein p18; Metablastin; Oncoprotein 18; OP 18; OP18; p18; p19; Phosphoprotein 19; Phosphoprotein p19; PP17; PP19; PR22; Pr22 protein; Prosolin; Protein Pr22; SMN; Stathmin; Stathmin1; STMN 1; STMN1; STMN1_HUMAN.|
|研究领域||肿瘤 细胞生物 免疫学 神经生物学 信号转导 细胞粘附分子 细胞骨架|
|交叉反应||Human, Mouse, Rat, Cow, Rabbit,|
|产品应用||WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||17kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthesised phosphopeptide derived from human Stathmin 1 around the phosphorylation site of Ser24:IL(p-S)PR|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.
Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
Belongs to the stathmin family.
Contains 1 SLD (stathmin-like) domain.
Entrez Gene: 3925 Human
Entrez Gene: 16765 Mouse
Entrez Gene: 29332 Rat
Omim: 151442 Human
SwissProt: P16949 Human
SwissProt: P54227 Mouse
SwissProt: P13668 Rat
Unigene: 209983 Human
Unigene: 378957 Mouse
Unigene: 555 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
原癌基因蛋白18(oncogene protein 18,Op18),是一种广泛存在于细胞质的蛋白质,可与微管蛋白结合,参与微管和纺锤体的组装;与细胞的增殖、分化、再生和运动均有关,并具有信号活性调节的功能。在细胞增殖、分化的信号途径、传到通路激活中也具有多种调节功能。