磷酸化芳香胺N-乙酰化转移酶抗体上海沪震实业有限公司

性能参数

产品名称: 磷酸化芳香胺N-乙酰化转移酶抗体
英文名称: phospho-AANAT (Thr29)
抗体货号: hz-
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
更新时间: 2018/4/16 14:29:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-phospho-AANAT (Thr29) antibody

 

产品编号 hz-11448R
英文名称 phospho-AANAT (Thr29)
中文名称 ***酸化芳香胺N-乙酰化转移酶抗体
别    名 p-AANAT(Thr29); p-AANAT(T29); AANAT(phospho Thr29); p-AANAT(phospho-T29); Serotonin N-acetyltransferase (phospho T29); AANAT (phospho-Thr29); AANAT; Arylalkylamine N acetyltransferase; SNAT_HUMAN; Serotonin N-acetyltransferase; SNAT; Serotonin acetylase; Aralkylamine N-acetyltransferase; AA-NAT.  
   
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  免疫学  神经生物学  信号转导  新陈代谢  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human AANAT around the phosphorylation site of Thr29:RH(p-T)LP 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
Arylalkylamine N-acetyltransferase belongs to the superfamily of acetyltransferases. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for seasonal reproduction, modulates the function of the circadian clock in the suprachiasmatic nucleus, and influences activity and sleep. This enzyme is rapidly inactivated when animals are exposed to light at night. This protein is 80% identical to sheep and rat AA-NAT. Arylalkylamine N-acetyltransferase may contribute a multifactorial genetic diseases such as altered behavior in sleep/wake cycle.

Function:
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.

Subunit:
Monomer. Interacts with several 14-3-3 proteins, including YWHAB, YWHAE, YWHAG and YWHAZ, preferentially when phosphorylated at Thr-31. Phosphorylation on Ser-205 also allows binding to YWHAZ, but with lower affinity. The interaction with YWHAZ considerably increases affinity for arylalkylamines and acetyl-CoA and protects the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation.

Subcellular Location:
Cytoplasmic

Tissue Specificity:
Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.

Post-translational modifications:
cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.

DISEASE:
Delayed sleep phase syndrome (DSPS) [MIM:614163]: A circadian rhythm sleep disorder characterized by sleep-onset insomnia and difficulty in awakening at the desired time. Patients with DSPS have chronic difficulty in adjusting their sleep-onset and wake-up times to occupational, school, and social activities. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Susceptibility to delayed sleep phase syndrome can be conferred by variant Thr-129. Thr-129 shows a significantly higher frequency in affected individuals than in healthy controls.

Similarity:
Belongs to the acetyltransferase family. AANAT subfamily.
Contains 1 N-acetyltransferase domain.

Gene ID:
15

Database links:

Entrez Gene: 503504 Chimpanzee

Entrez Gene: 15 Human

Entrez Gene: 11298 Mouse

Entrez Gene: 25120 Rat

SwissProt: P79774 Chicken

SwissProt: Q5IS55 Chimpanzee

SwissProt: Q16613 Human

SwissProt: O88816 Mouse

SwissProt: Q64666 Rat

Unigene: 431417 Human

Unigene: 418559 Mouse

Unigene: 42233 Mouse

Unigene: 88180 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

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