磷酸化离子通道蛋白Kv1.3抗体上海沪震实业有限公司

性能参数

产品名称: 磷酸化离子通道蛋白Kv1.3抗体
英文名称: phospho-KCNA3 (Tyr135)
抗体货号: hz-12171R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
更新时间: 2018/4/16 14:43:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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上海·中国-上海
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产品详细描述

 Rabbit Anti-phospho-KCNA3 (Tyr135) antibody

 

产品编号 hz-12171R
英文名称 phospho-KCNA3 (Tyr135)
中文名称 ***酸化离子通道蛋白Kv1.3抗体
别    名 KCNA3 (phospho Y135); p-KCNA3 (phospho Y135); KCNA3 (phospho Y135); p-KCNA3 (phospho Y135); p-KV1.3 (phospho Y135); Potassium Channel Kv1.3; HGK 5; HGK5; HLK 3; HLK3; HPCN 3; HPCN3; HuKIII; KCNA 3; KCNA3; KV1.3; MK 3; MK3; PCN 3; PCN3; Potassium channel 3; Potassium voltage gated channel shaker related subfamily member 3; Potassium voltage gated channel subfamily A member 3; Type n potassium channel; Voltage gated potassium channel subunit Kv1.3; KCNA3_HUMAN.  
   
产品类型 ***酸化抗体 
研究领域 细胞生物  神经生物学  信号转导  通道蛋白  转运蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep, 
产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 64kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human KCNA3 around the phosphorylation site of Tyr135:RF(p-Y)QL 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008].

Function:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit:
Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4.


Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily.
Kv1.3/KCNA3 sub-subfamily.

Gene ID:
3738

Database links:

Entrez Gene: 3738 Human

Entrez Gene: 16491 Mouse

Entrez Gene: 29731 Rat

Omim: 176263 Human

SwissProt: P22001 Human

SwissProt: P16390 Mouse

SwissProt: P15384 Rat

Unigene: 169948 Human

Unigene: 30640 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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