Rabbit Anti-phospho-Kv2.1(Ser805) antibody
|别 名||Kv2.1 (phospho S805); p-Kv2.1(phospho Ser805); Delayed rectifier potassium channel 1; Delayed rectifier potassium channel Kv2.1; DRK 1; DRK1; h DRK1 K(+) channel; h-DRK1; hDRK 1; hDRK1; KCB 1; KCB1; KCNB1; KCNB1_HUMAN; KV2.1 ; Potassium channel protein DRK1; Potassium voltage gated channel shab related subfamily member 1; Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel subunit Kv2.1.|
|研究领域||神经生物学 通道蛋白 细胞膜受体|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,|
|产品应用||ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||96kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthesised phosphopeptide derived from human Kv2.1 around the phosphorylation site of Ser805:PT(p-S)PK|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq].
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.
Heteromultimer with KCNG2, KCNG3, KCNG4, KCNS1, KCNS2, KCNS3 and KCNV2 (By similarity).
Highly phosphorylated on serine residues in the C-terminal. Differential phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating. Phosphorylation on Ser-457, Ser-541, Ser-567, Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are all regulated by calcineurin-mediated dephosphorylation. Particularly, Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through phosphorylation/ dephosphorylation activities. Tyr-128 can be dephosphorylated by PTPalpha and cyt-PTPepsilon. Phosphorylation levels on Ser-607 are supersensitive to neuronal activity. Phosphorylation on Ser-567 is reduced during postnatal development with low levels at P2 and P5. Levels then increase to reach adult levels by P14. Phosphorylation levels on Ser-564 and Ser-607 are greatly reduced during seizures, by 40% and 85% respectively.
Belongs to the potassium channel family.
B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
Entrez Gene: 3745 Human
Entrez Gene: 16500 Mouse
Entrez Gene: 25736 Rat
Omim: 600397 Human
SwissProt: Q14721 Human
SwissProt: Q03717 Mouse
SwissProt: P15387 Rat
Unigene: 84244 Human
Unigene: 387390 Mouse
Unigene: 26724 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications