磷酸化凋亡相关蛋白激酶1抗体上海沪震实业有限公司

性能参数

产品名称: 磷酸化凋亡相关蛋白激酶1抗体
英文名称: phospho-DAP Kinase 1 (Ser308)
抗体货号: hz-12576R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
更新时间: 2018/4/16 15:15:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-phospho-DAP Kinase 1 (Ser308) antibody 

 

产品编号 hz-12576R
英文名称 phospho-DAP Kinase 1 (Ser308)
中文名称 ***酸化凋亡相关蛋白激酶1抗体
别    名 DAP Kinase 1 (phospho Ser308); DAP Kinase 1 (phospho S308); DAK1; DAP K1; DAP kinase 1; DAPK 1; DAPK; DAPK1; DAPK1_HUMAN; Death Associated Protein Kinase 1; Death-associated protein kinase 1; DKFZp781I035;  
   
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  信号转导  细胞凋亡  新陈代谢  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 157kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human DAP Kinase 1 around the phosphorylation site of Ser308: 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
DAPK1 expression is frequently lost in human carcinomas and B-cell leukemia, and lower levels of expression correlates with high rates of metastasis. The loss of DAPK expression provides a link between suppression of apoptosis and metastasis. DAPK1 is thought be involved in an early apoptotic checkpoint which eliminates premalignant cells from cancer formation. Studies in bladder cancer patients have also shown that hypermethylation of DAPK1 correlates to high recurrence rates and thus DAPK1 may be used as a prognostic marker. DAPK1 is also reportedly a molecular regulator of neuronal death in epilepsy.

Function:
Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.

Subcellular Location:
Cytoplasm. Colocalizes with the actin filament system.

Post-translational modifications:
Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex, leading to its degradation by the proteasome.

Similarity:
Belongs to the protein kinase superfamily. 
CAMK Ser/Thr protein kinase family. 
DAP kinase subfamily. 
Contains 10 ANK repeats. 
Contains 1 death domain. 
Contains 1 protein kinase domain.

Gene ID:
1612

Database links:

Entrez Gene: 1612 Human

Entrez Gene: 69635 Mouse

Entrez Gene: 306722 Rat

Omim: 600831 Human

SwissProt: P53355 Human

SwissProt: Q80YE7 Mouse

Unigene: 380277 Human

Unigene: 693441 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

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