磷酸化丁酸盐反应因子1抗体
产品名称： 磷酸化丁酸盐反应因子1抗体
英文名称： phospho-ZFP36L1 (Ser92)
产品编号： hz-12902R
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
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Rabbit Anti-phospho-ZFP36L1 (Ser92) antibody
| 产品编号 | hz-12902R |
| 英文名称 | phospho-ZFP36L1 (Ser92) |
| 中文名称 | 磷酸化丁酸盐反应因子1抗体 |
| 别 名 | butyrate response factor 1 (phospho S92); ZFP36L1 (phospho S92); Berg36; BRF1; Butyrate response factor 1(phospho S334); C3H1 type-like 1; cMG1; Early response factor Berg36; EGF response factor 1; EGF-response factor 1; ERF 1; ERF-1; ERF1; Protein TIS11B; RNF162B; TIS11B; TISB_HUMAN; ZFP36L1; Zinc finger protein 36 C3H type like 1; zinc finger protein C3H type 36 like 1; BERG36; Zinc finger protein 36, C3H1 type-like 1. |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 细胞生物 发育生物学 信号转导 干细胞 生长因子和 转录调节因子 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human butyrate response factor 1 around the phosphorylation site of Ser92 [SF(p-S)EG]:SF(p-S)EG |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: EGF response factor 1 is a zinc-binding protein encoded by the immediate-early response gene, Zfp-36. TIS11B, a relative of TTP, localizes to the nucleus and may function as a transcription factor involved in regulating the growth factor response. It is an evolutionarily conserved protein containing two C3H1-type zinc fingers and a repeating cys-his motif. TIS11B is an mRNA binding protein and is known to interact with the 3’-untranslated region of VEGF mRNA, thereby decreasing its stability. This suggests that TIS11B is a potential target in antiangiogenic therapy. In addition, TIS11B may also be an important regulator of myogenesis, as its expression is upregulated during murine myoblast differentiation. Function: Butyrate response factor 1 is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating Cys-His motif. This putative nuclear transcription factor probably functions in regulating the response to growth factors. Subcellular Location: Nuclear. Similarity: Contains 2 C3H1-type zinc fingers. SWISS: Q07352 Gene ID: 677 Database links: Entrez Gene: 400223 Human Entrez Gene: 677 Human Entrez Gene: 12192 Mouse Entrez Gene: 29344 Rat Omim: 601064 Human SwissProt: Q07352 Human SwissProt: P23950 Mouse SwissProt: P17431 Rat Unigene: 707091 Human Unigene: 85155 Human Unigene: 235132 Mouse Unigene: 6142 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |