Rabbit Anti-phospho-gamma Adducin (Ser693) antibody
|英文名称||phospho-gamma Adducin (Ser693)|
|别 名||ADD3; ADDG_HUMAN; ADDL; Adducin 3 (gamma); Adducin 3; Adducin-like protein 70; Gamma-adducin.|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,|
|产品应用||ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||81kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthesised phosphopeptide derived from human gamma Adducin around the phosphorylation site of Ser693:TP(p-S)FL|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha and beta adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha and gamma adducins are ubiquitously expressed. In contrast, beta adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca2+/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
Heterodimer of an alpha and a gamma subunit.
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Isoform 1 is ubiquitously expressed.
Belongs to the aldolase class II family. Adducin subfamily.
Entrez Gene: 120 Human
Entrez Gene: 27360 Mouse
Entrez Gene: 25230 Rat
Omim: 601568 Human
SwissProt: Q9UEY8 Human
SwissProt: Q9QYB5 Mouse
SwissProt: Q62847 Rat
Unigene: 501012 Human
Unigene: 426080 Mouse
Unigene: 76589 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications