磷酸化转录调节因子CEBP β抗体上海沪震实业有限公司

性能参数

产品名称: 磷酸化转录调节因子CEBP β抗体
英文名称: Phospho-CEBP beta (Thr188)
抗体货号: hz-13819R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
更新时间: 2018/4/17 14:23:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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021-31320307
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上海·中国-上海
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产品详细描述

 Rabbit Anti-Phospho-CEBP beta (Thr188) antibody

 

产品编号 hz-13819R
英文名称 Phospho-CEBP beta (Thr188)
中文名称 ***酸化转录调节因子CEBP β抗体
别    名 CEBP Beta (phospho T188); p-CEBP Beta (phospho T188); CEBP-beta; CLEBP beta; CCAAT Enhancer Binding Protein beta; AGP/EBP; C EBP beta; C/EBP related protein 2; CEBPB; CRP2; IL 6DBP; IL6DBP; Interleukin 6 dependent binding protein; LAP; Liver enriched transcriptional activator; NF IL6; NFIL6; Nuclear factor NF IL6; SF B; SFB; Silencer factor B; TCF5; Transcription factor 5).   
   
   
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  信号转导  细胞凋亡  转录调节因子  激酶和***酸酶  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33(mo, rat)/38(hkDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from mouse CEBP beta around the phosphorylation site of Thr188:PG(p-T)PS 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP alpha, CEBP delta, and CEBP gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL1 response element in the IL6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.

Function:
Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Subunit : Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha and gamma. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B. Forms a complex with THOC5 (By similarity). Interacts with ZNF638; this interaction increases transcriptional activation (By similarity).

Subcellular Location:
Nucleus.

Post-translational modifications:
Sumoylated by polymeric chains of SUMO2 or SUMO3.

Similarity:
Belongs to the bZIP family. C/EBP subfamily.
Contains 1 bZIP domain.

SWISS:
P28033

Gene ID:
12608

Database links:

Entrez Gene: 1051 Human

Entrez Gene: 12608 Mouse

Entrez Gene: 24253 Rat

Omim: 189965 Human

SwissProt: P17676 Human

SwissProt: P28033 Mouse

SwissProt: P21272 Rat

Unigene: 517106 Human

Unigene: 719041 Human

Unigene: 720603 Human

Unigene: 439656 Mouse

Unigene: 6479 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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