磷酸化皮层肌动蛋白抗体
产品名称： 磷酸化皮层肌动蛋白抗体
英文名称： phospho-Cortactin (Tyr421)
产品编号： hz-14000R
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ELISA=1:500-1000 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
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Rabbit Anti-phospho-Cortactin (Tyr421) antibody
| 产品编号 | hz-14000R |
| 英文名称 | phospho-Cortactin (Tyr421) |
| 中文名称 | 磷酸化皮层肌动蛋白抗体 |
| 别 名 | Cortactin (phospho Y421); p-Cortactin (phospho Y421); Amplaxin; CTTN; EMS 1; EMS1; FLJ34459; Mammary tumor and squamous cell carcinoma associated; Oncogene EMS1; p80/85 src substrate; Src substrate cortactin; SRC8_HUMAN. |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 信号转导 细胞凋亡 激酶和磷酸酶 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Rabbit, |
| 产品应用 | ELISA=1:500-1000 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 62kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human Cortactin around the phosphorylation site of Tyr421:PV(p-Y)ED |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010] Function: Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases. Subcellular Location: Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cell projection > ruffle. Associated with membrane ruffles and lamellipodia. Post-translational modifications: Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Similarity: Contains 7 cortactin repeats. Contains 1 SH3 domain. SWISS: Q14247 Gene ID: 2017 Database links: Entrez Gene: 2017 Human Entrez Gene: 13043 Mouse Entrez Gene: 60465 Rat GenBank: NM_138565 Human GenBank: NM_007803 Mouse Omim: 164765 Human SwissProt: Q14247 Human SwissProt: Q60598 Mouse Unigene: 596164 Human Unigene: 205601 Mouse Unigene: 107869 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |