磷酸化皮层肌动蛋白抗体上海沪震实业有限公司

性能参数

产品名称: 磷酸化皮层肌动蛋白抗体
英文名称: phospho-Cortactin (Tyr421)
抗体货号: hz-14000R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: ELISA=1:500-1000 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
更新时间: 2018/7/27 12:06:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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上海·中国-上海
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产品详细描述

 Rabbit Anti-phospho-Cortactin (Tyr421) antibody

 

产品编号 hz-14000R
英文名称 phospho-Cortactin (Tyr421)
中文名称 ***酸化皮层肌动蛋白抗体
别    名 Cortactin (phospho Y421); p-Cortactin (phospho Y421); Amplaxin; CTTN; EMS 1; EMS1; FLJ34459; Mammary tumor and squamous cell carcinoma associated; Oncogene EMS1; p80/85 src substrate; Src substrate cortactin; SRC8_HUMAN.  
   
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  信号转导  细胞凋亡  激酶和***酸酶  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Rabbit, 
产品应用 ELISA=1:500-1000 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 62kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Cortactin around the phosphorylation site of Tyr421:PV(p-Y)ED 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

Function:
Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.

Subcellular Location:
Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cell projection > ruffle. Associated with membrane ruffles and lamellipodia.

Post-translational modifications:
Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.

Similarity:
Contains 7 cortactin repeats.
Contains 1 SH3 domain.

SWISS:
Q14247

Gene ID:
2017

Database links:

Entrez Gene: 2017 Human

Entrez Gene: 13043 Mouse

Entrez Gene: 60465 Rat

GenBank: NM_138565 Human

GenBank: NM_007803 Mouse

Omim: 164765 Human

SwissProt: Q14247 Human

SwissProt: Q60598 Mouse

Unigene: 596164 Human

Unigene: 205601 Mouse

Unigene: 107869 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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