磷酸化染色质相关蛋白1-γ抗体上海沪震实业有限公司

性能参数

产品名称: 磷酸化染色质相关蛋白1-γ抗体
英文名称: phospho-HP1 gamma (Ser83)
抗体货号: hz-17374R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
更新时间: 2018/4/17 15:03:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-phospho-HP1 gamma (Ser83) antibody

 

产品编号 hz-17374R
英文名称 phospho-HP1 gamma (Ser83)
中文名称 ***酸化染色质相关蛋白1-γ抗体
别    名 HP1 gamma (phospho S83); p-HP1 gamma (phospho S83); CBX 3; CBX3; CBX3_HUMAN; Chromobox homolog 3 (HP1 gamma homolog, Drosophila); Chromobox homolog 3; Chromobox protein homolog 3; GAMMA; HECH; Heterochromatin like protein 1; Heterochromatin protein 1 homolog gamma; Heterochromatin protein HP1 gamma; Heterochromatin protein HP1 gamma; HP1 gamma; HP1 gamma homolog; HP1 gamma homolog; HP1Hs gamma; HP1Hs gamma; Modifier 2 protein; Modifier 2 protein; S83.  HP-1-γ; HP 1γ; HP-1γ; HP-1 γ; HP1γ; HP1 γ;
   
产品类型 ***酸化抗体 
研究领域 细胞生物  结合蛋白  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Rhesus monkey
产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 24kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human HP1 gamma around the phosphorylation site of Ser83: 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
HP1 gamma appears to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. HP1 gamma may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) and involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Function:
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Subcellular Location:
Nucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis.

Post-translational modifications:
Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.

Similarity:
Contains 2 chromo domains.

Gene ID:
11335

Database links:

Entrez Gene: 539788 Cow

Entrez Gene: 11335 Human

Entrez Gene: 12417 Mouse

Entrez Gene: 706978 Rhesus monkey

Omim: 604477 Human

SwissProt: Q13185 Human

SwissProt: P23198 Mouse

SwissProt: Q5R6X7 Orangutan

Unigene: 381189 Human

Unigene: 280968 Mouse

Unigene: 458234 Mouse

Unigene: 485141 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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