磷酸化DNA拓普西异构酶Ⅱ抗体上海沪震实业有限公司

性能参数

产品名称: 磷酸化DNA拓普西异构酶Ⅱ抗体
英文名称: phospho-Topoisomerase II alpha (Thr1343)
抗体货号: hz-17593R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: WB=1:500-2000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
更新时间: 2018/4/17 15:14:00
详细资料:  实验方法技术资料
浏览人数:15
诚信指数:730点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-phospho-Topoisomerase II alpha (Thr1343) antibody

 

产品编号 hz-17593R
英文名称 phospho-Topoisomerase II alpha (Thr1343)
中文名称 ***酸化DNA拓普西异构酶Ⅱ抗体
别    名 Topoisomerase II alpha (phospho T1343); alpha isozyme; ATP hydrolyzing DNA topoisomerase II alfa; DNA gyrase; DNA topoisomerase 2 alpha; DNA topoisomerase 2-alpha; DNA topoisomerase II 170 kD; DNA topoisomerase II alpha isozyme; DNA topoisomerase II; DNA Topoisomerase2; TOP 2A; TOP2; TOP2A; TOP2A_HUMAN; Topoisomerase DNA II alpha 170kDa; TP2A; Topo IIα; Topo-IIα.  
   
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 WB=1:500-2000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 174kDa
细胞定位 细胞核 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Topoisomerase II alpha around the phosphorylation site of Thr1343:EK(p-T)D 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]

Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

Subcellular Location:
Cytoplasm. Nucleus > nucleoplasm. Generally located in the nucleoplasm.

Post-translational modifications:
Phosphorylation has no effect on catalytic activity.

Similarity:
Belongs to the type II topoisomerase family.

SWISS:
P11388

Gene ID:
7153

Database links:

Entrez Gene: 7153 Human

Entrez Gene: 21973 Mouse

Entrez Gene: 360243 Rat

Omim: 126430 Human

SwissProt: P11388 Human

SwissProt: Q01320 Mouse

SwissProt: P41516 Rat

Unigene: 156346 Human

Unigene: 4237 Mouse

Unigene: 90996 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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