磷酸化SH3结构域结合蛋白2抗体上海沪震实业有限公司

性能参数

产品名称: 磷酸化SH3结构域结合蛋白2抗体
英文名称: phospho-SH3BP2 (Ser427)
抗体货号: hz-19750R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
更新时间: 2018/4/18 14:01:00
详细资料:  实验方法技术资料
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诚信指数:730点
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-phospho-SH3BP2 (Ser427) antibody 

 

产品编号 hz-19750R
英文名称 phospho-SH3BP2 (Ser427)
中文名称 ***酸化SH3结构域结合蛋白2抗体
别    名 SH3BP2 (phospho S427); p-SH3BP2 (phospho S427); 3BP-2; 3BP2; 3BP2_HUMAN; Abl SH3 binding protein 2; Cherubism; CRBM; CRPM; FLJ42079; FLJ54978; RES4-23; SH3 domain binding protein 2; SH3 domain-binding protein 2; Sh3bp2; TNFAIP3 interacting protein 2.  
   
产品类型 ***酸化抗体 
研究领域 细胞生物  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Cow, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 62kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human SH3BP2 around the phosphorylation site of Ser427:SF(p-S)FE 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Function:
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.

Tissue Specificity:
Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.

DISEASE:
Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:118400]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.

Similarity:
Contains 1 PH domain.
Contains 1 SH2 domain.

Gene ID:
6452

Database links:

Entrez Gene: 6452 Human

Omim: 602104 Human

SwissProt: P78314 Human

Unigene: 167679 Human

 

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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