磷酸化视网膜色素变性蛋白4抗体上海沪震实业有限公司

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产品名称: 磷酸化视网膜色素变性蛋白4抗体
英文名称: phospho-Rhodopsin (Ser334)
抗体货号: hz-19873R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
更新时间: 2018/8/15 11:26:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-phospho-Rhodopsin (Ser334) antibody 

 

产品编号 hz-19873R
英文名称 phospho-Rhodopsin (Ser334)
中文名称 ***酸化视网膜色素变性蛋白4抗体
别    名 Rhodopsin (phospho S334); p-Rhodopsin (phospho S334); CSNBAD1; MGC138309; MGC138311; OPN 2; OPN2; opsd; OPSD_HUMAN; Opsin 2; opsin 2; Opsin 2 rod pigment; Opsin-2; Opsin2; Retinitis Pigmentosa 4; Retinitis pigmentosa 4 autosomal dominant; RHO; Rhodopsin; RP 4; RP4.  
   
产品类型 ***酸化抗体 
研究领域 细胞生物  神经生物学  信号转导  干细胞  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Rat, Rabbit, 
产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Rhodopsin around the phosphorylation site of Ser334.:EA(p-S)AT 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]

Function:
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.

Subcellular Location:
Membrane. Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia.

Tissue Specificity:
Rod shaped photoreceptor cells which mediates vision in dim light.

Post-translational modifications:
Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
Contains one covalently linked retinal chromophore.

DISEASE:
Retinitis pigmentosa 4.
Night blindness, congenital stationary, autosomal dominant 1

Similarity:
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Gene ID:
6010

Database links:

Entrez Gene: 6010 Human

Entrez Gene: 212541 Mouse

Entrez Gene: 24717 Rat

Omim: 180380 Human

SwissProt: P08100 Human

SwissProt: P15409 Mouse

SwissProt: P51489 Rat

Unigene: 247565 Human

Unigene: 2965 Mouse

Unigene: 406156 Mouse

Unigene: 92530 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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