磷酸化肌球蛋白调节多肽9抗体上海沪震实业有限公司

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产品名称: 磷酸化肌球蛋白调节多肽9抗体
英文名称: phospho-MYL9 (Thr19 + Ser20)
抗体货号: hz-17799R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
更新时间: 2018/8/5 11:24:00
详细资料:  实验方法技术资料
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诚信指数:962点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
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电话:
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上海·中国-上海
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产品详细描述

 Rabbit Anti-phospho-MYL9 (Thr19 + Ser20) antibody

 

产品编号 hz-17799R
英文名称 phospho-MYL9 (Thr19 + Ser20)
中文名称 ***酸化肌球蛋白调节多肽9抗体
别    名 MYL9 (phospho T19 + S20); p-MLC(Thr19 + Ser20); phospho-MLC(Thr19 + Ser20); p-Myosin light chain(Thr19 + Ser20); MYL9_HUMAN; Myosin regulatory light polypeptide 9; 20 kDa myosin light chain; LC20; MLC-2C; Myosin RLC; Myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 9; Myosin regulatory light chain MRLC1; MLC2; MRLC1; MYRL2.  
   
产品类型 ***酸化抗体 
研究领域 心血管  细胞生物  信号转导  干细胞  细胞骨架  细胞膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Danio
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 20kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human MYL9 around the phosphorylation site of Thr19 + Ser20:RA(p-T)(p-S)N 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
MYL9 is the myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. MYL9 protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for MYL9 and the deduced 172-amino acid protein is highly conserved, with only 3 differences between the human and chicken proteins. Light chain phosphorylation causes the folded monomeric form of myosin to extend and assemble into filaments. This observation established the involvement of the MYL9 in conformational transitions of smooth muscle myosin.

Function:
Myosin light chain (MLC) is a subunit of the conventional myosins (e.g. myosin II). In smooth muscle and non-muscle cells conventional myosins mediate a wide variety of contractile events including cytokinesis, cell motility, and smooth muscle contraction. MLC is phosphorylated by multiple serine-threonine kinases such as Rho-kinase and PAK, however myosin light chain kinase (MLCK) acts as the primary kinase. Contractile activity of conventional myosins is regulated by phosphorylation of MLC on several residues.

Subunit:
Myosin is an hexamer of 2 heavy chains and 4 light chains.

Tissue Specificity:
Smooth muscle tissues and in some, but not all, nonmuscle cells.

Post-translational modifications:
Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity).

Similarity:
Contains 3 EF-hand domains.

Gene ID:
10398

Database links:

Entrez Gene: 10398 Human

Entrez Gene: 85366 Human

Entrez Gene: 228785 Mouse

Entrez Gene: 98932 Mouse

Entrez Gene: 117558 Rat

Entrez Gene: 296313 Rat

Omim: 606566 Human

Omim: 609905 Human

SwissProt: P20689 Human

SwissProt: P24844 Human

SwissProt: Q8VCR8 Mouse

SwissProt: Q9CQ19 Mouse

SwissProt: P20689 Rat

SwissProt: Q64122 Rat

Unigene: 504687 Human

Unigene: 271770 Mouse

Unigene: 228729 Rat

Unigene: 6870 Rat

 

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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