α-辅肌动蛋白1抗体上海沪震实业有限公司

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产品名称: α-辅肌动蛋白1抗体
英文名称: Alpha-actinin-1
抗体货号: hz-33272M
产品规格: 50ul/100ul/200ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 580-1600元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: ELISA=1:500-1000 IHC-P=1:500-1000 IHC-F=1:500-1000 ICC=1:100-500 IF=1:500-1000
更新时间: 2018/8/24 12:51:00
详细资料:  实验方法技术资料
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诚信指数:962点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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上海·中国-上海
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产品详细描述

 Mouse Anti-Alpha-actinin-1 antibody

 

产品编号 hz-33272M
英文名称 Alpha-actinin-1
中文名称 α-辅肌动蛋白1抗体
别    名 ACTN 1; ACTN1_HUMAN; Alpha Actinin 1; Alpha actinin cytoskeletal isoform; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; FLJ40884; FLJ54432; Actinin Alpha 1; F-Actin Cross-Linking Protein; Non-Muscle Alpha-Actinin-1; Actinin, Alpha 1; Actinin 1 Smooth Muscle; BDPLT15;   
   
产品类型 内参抗体 
研究领域 细胞生物  发育生物学  细胞骨架  
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 6A10
交叉反应 Human, Mouse, Rat, 
产品应用 ELISA=1:500-1000 IHC-P=1:500-1000 IHC-F=1:500-1000 ICC=1:100-500 IF=1:500-1000 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 103kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 Recombinant human Alpha-actinin-1 protein: 
亚    型 IgG
纯化方法 affinity purified by Protein G
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.

Subunit:
Homodimer; antiparallel. Interacts with DDN, MYOZ2, PDLIM2, TTID and LPP. Interacts with PSD. Interacts with MICALL2 (By similarity). Interacts with DNM2 and CTTN (By similarity).

Subcellular Location:
Cytoplasm > cytoskeleton. 
Cytoplasm > myofibril > sarcomere > Z line. 
Cell membrane.
Cell junction.
Cell projection › ruffle.

Similarity:
Belongs to the alpha-actinin family.
Contains 1 actin-binding domain.
Contains 2 CH (calponin-homology) domains.
Contains 2 EF-hand domains.
Contains 4 spectrin repeats.

Gene ID:
87

Database links:

Entrez Gene: 87 Human

Entrez Gene: 109711 Mouse

Entrez Gene: 81634 Rat

Omim: 102575 Human

SwissProt: P12814 Human

SwissProt: Q7TPR4 Mouse

SwissProt: Q9Z1P2 Rat

Unigene: 509765 Human

Unigene: 253564 Mouse

Unigene: 403477 Mouse

Unigene: 6401 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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