乙酰化组蛋白H4(K16)抗体-抗体-抗体-生物在线
乙酰化组蛋白H4(K16)抗体

乙酰化组蛋白H4(K16)抗体

商家询价

产品名称: 乙酰化组蛋白H4(K16)抗体

英文名称: Histone H4 (Acetyl K16)

产品编号: hz-4707R

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:50-200

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 Rabbit Anti-Histone H4 (Acetyl K16) antibody 

 

产品编号 hz-4707R
英文名称 Histone H4 (Acetyl K16)
中文名称 乙酰化组蛋白H4(K16)抗体
别    名 Histone H4 (Acetyl K16); Histone H4 (Acetyl Lys16); Acetyl-Histone H4(K16); Acetyl-Histone H4 (Lys16); H4F2; H4FN; HIST1H4; HIST2H4; HISTH4H4; methyl histone H4; histone H4; H4_HUMAN; Osteogenic growth peptide; OGP.  
   
产品类型 乙酰化抗体 
研究领域 细胞生物  免疫学  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:50-200 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 11kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLKLH conjugated Synthesised acetylpeptide derived from human Histone H4 around the acetylation site of K16:GA(Ac-K)RH 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Jul 2008].

Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subunit:
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Subcellular Location:
Nucleus. Chromosome.

Post-translational modifications:
Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. 
Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. 
Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. 
Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing. 
Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4. 
Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me). 
Sumoylated, which is associated with transcriptional repression. 
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.

Similarity:
Belongs to the histone H4 family.

SWISS:
P62805

Gene ID:
121504

Database links:

Entrez Gene: 121504 Human

Entrez Gene: 554313 Human

Entrez Gene: 8294 Human

Entrez Gene: 8359 Human

Entrez Gene: 8360 Human

Entrez Gene: 8361 Human

Entrez Gene: 8362 Human

Entrez Gene: 8363 Human

Entrez Gene: 8364 Human

Entrez Gene: 8365 Human

Entrez Gene: 8366 Human

Entrez Gene: 8367 Human

Entrez Gene: 8368 Human

Entrez Gene: 8370 Human

Entrez Gene: 100041230 Mouse

Entrez Gene: 100862646 Mouse

Entrez Gene: 319155 Mouse

Entrez Gene: 319156 Mouse

Entrez Gene: 319157 Mouse

Entrez Gene: 319158 Mouse

Entrez Gene: 319159 Mouse

Entrez Gene: 319160 Mouse

Entrez Gene: 319161 Mouse

Entrez Gene: 320332 Mouse

Entrez Gene: 326619 Mouse

Entrez Gene: 326620 Mouse

Entrez Gene: 69386 Mouse

Entrez Gene: 97122 Mouse

GenBank: NM_003548 Human

Omim: 142750 Human

SwissProt: P84040 Fruit fly (Drosophila melanogaster)

SwissProt: P02304 Human

SwissProt: P62805 Human

SwissProt: P02304 Mouse

SwissProt: P62806 Mouse

SwissProt: P02304 Rat

SwissProt: P09322 Schizosaccharomyces pombe

Unigene: 21500 Fruit fly (Drosophila melanogaster)

Unigene: 29514 Fruit fly (Drosophila melanogaster)

Unigene: 29527 Fruit fly (Drosophila melanogaster)

Unigene: 30219 Fruit fly (Drosophila melanogaster)

Unigene: 30220 Fruit fly (Drosophila melanogaster)

Unigene: 30221 Fruit fly (Drosophila melanogaster)

Unigene: 30223 Fruit fly (Drosophila melanogaster)

Unigene: 30868 Fruit fly (Drosophila melanogaster)

Unigene: 30869 Fruit fly (Drosophila melanogaster)

Unigene: 30871 Fruit fly (Drosophila melanogaster)

Unigene: 30872 Fruit fly (Drosophila melanogaster)

Unigene: 30873 Fruit fly (Drosophila melanogaster)

Unigene: 30876 Fruit fly (Drosophila melanogaster)

Unigene: 33873 Fruit fly (Drosophila melanogaster)

Unigene: 5747 Fruit fly (Drosophila melanogaster)

Unigene: 143080 Human

Unigene: 247816 Human

Unigene: 248172 Human

Unigene: 248178 Human

Unigene: 248179 Human

Unigene: 278483 Human

Unigene: 352191 Human

Unigene: 46423 Human

Unigene: 528055 Human

Unigene: 533295 Human

Unigene: 55468 Human

Unigene: 591790 Human

Unigene: 655235 Human

Unigene: 662174 Human

Unigene: 706635 Human

Unigene: 742244 Human

Unigene: 14775 Mouse

Unigene: 158272 Mouse

Unigene: 227295 Mouse

Unigene: 228709 Mouse

Unigene: 246720 Mouse

Unigene: 255646 Mouse

Unigene: 260530 Mouse

Unigene: 261642 Mouse

Unigene: 261662 Mouse

Unigene: 261664 Mouse

Unigene: 377875 Mouse

Unigene: 442307 Mouse

Unigene: 486099 Mouse

Unigene: 489077 Mouse