FITC标记的TSK蛋白抗体-抗体-抗体-生物在线
FITC标记的TSK蛋白抗体

FITC标记的TSK蛋白抗体

商家询价

产品名称: FITC标记的TSK蛋白抗体

英文名称: Anti-Tsukushin/FITC

产品编号: HZ-11607R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ICC=1:50-200 IF=1:50-200

上海沪震实业有限公司
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  • 所在区域 : 上海
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 Rabbit Anti-Tsukushin/FITC Conjugated antibody

FITC标记的TSK蛋白抗体

 

产品编号 bs-11607R-FITC
英文名称 Anti-Tsukushin/FITC
中文名称 FITC标记的TSK蛋白抗体
别    名 E2 induced gene 4 protein; E2IG4; Leucine rich repeat containing protein 54; LRRC54; TSK; Tsukushi; TSK_HUMAN; Tsukushin.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  干细胞  生长因子和激素  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Tsukushin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. LRRC54 (leucine-rich repeat-containing protein 54), also known as tsukushin, TSKU or E2-induced gene 4 protein (E2IG4), is a 353 amino acid secreted protein that likely localizes to the cell membrane and extracellular compartments. Involved in extracellular secretion and intracellular transport, LRRC54 can be induced by 17-beta-estradiol. Containing nine LRR repeat and a cleavable signal peptide, the gene encoding LRRC54 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

Function:
It is suggested that Tsukushin is involved in intracellular transport and extracellular secretion. Its structure contains 9 LRR (leucine-rich) repeats.

Subcellular Location:
Secreted

Similarity:
Contains 10 LRR (leucine-rich) repeats. 
Contains 1 LRRNT domain. 

Database links:

Entrez Gene: 25987 Human

GenBank: NM_015516 Human

GenBank: NP_056331 Human

Omim: 608015 Human

SwissProt: Q8WUA8 Human

Unigene: 8361 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
   

富含亮氨酸(LRR)的重复序列是20-30个氨基酸基序,形成疏水性/马蹄形褶皱,允许其在紧密堆积的核心内容纳多个亮氨酸残基。所有的LRR重复包含可变片段和高度保守的片段,后者占整个LRR基序的11或12个残基。LRRC54(富含亮氨酸重复序列的含蛋白质54),也称为Tukkuin,TSKU或E2诱导的基因4蛋白(E2IG4),是一种353氨基酸分泌蛋白,可能定位于细胞膜和细胞外室。17β-雌二醇可诱导LRRC54在细胞外分泌和胞内转运。含有九个LRR重复序列和一个可裂解信号肽,编码LRRC54的基因映射到人类11号染色体,其含有超过1400个基因,并且包含人类基因组的近4%。Jevl和Lange Nielsen综合征、杰克布森综合征、尼曼匹克病、遗传性血管水肿和Smith-LeMi-Opz综合征与11号染色体上的基因缺陷有关。