FITC标记的感光细胞转录因子TULP3抗体上海沪震实业有限公司

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产品名称: FITC标记的感光细胞转录因子TULP3抗体
英文名称: Anti-TULP3/FITC
抗体货号: HZ-11605R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/23 12:18:00
详细资料:  实验方法技术资料
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诚信指数:1026点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-TULP3/FITC Conjugated antibody

FITC标记的感光细胞转录因子TULP3抗体

 

产品编号 bs-11605R-FITC
英文名称 Anti-TULP3/FITC
中文名称 FITC标记的感光细胞转录因子TULP3抗体
别    名 Tubby like protein 3; Tubby related protein 3; Tubby-like protein 3; Tubby-related protein 3; TUBL 3; TUBL3; TULP 3; TULP3; TULP3_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Horse, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TULP3 (251-350aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Mutations in the mouse Tub gene gradually lead to obesity, strongly resembling the late-onset obesity observed in the human population. In addition to excessive deposition of adipose tissue, mice with the Tub phenotype also suffer retinal degeneration and neurosensory hearing loss. A human homolog of the Tub gene has been identified, as have three related proteins, called Tubby-like protein 1 (TULP1), TULP2 and TULP3. When compared to TULP1 and TULP2, TULP3 has a wider tissue expression and is phylogenetically more similar to Tub than either TULP1 or TULP2. TULP1, expressed specifically in the retina, maps to the chromosomal region known to be involved in retinitis pigmentosa, while TULP2 maps within the minimal interval for the rod-cone dystrophy. TULP3 maps to human chromosome 12p13, and shares 69% homology to mouse TULP3. Human RNA from testis, ovary, thyroid and spinal cord contain highly detectable levels of TULP3 transcripts. In the retina, TULP3 is expressed specifically in the inner nuclear layer and ganglion cell layer. TULP1, TULP2 and TULP3 may comprise a unique family of bipartite transcription factors.

Function:
Negatively regulates SHH signal transduction (By similarity). Probably functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to phosphorylated inositide lipids.

Subcellular Location:
Nucleus. Cell membrane. Cell projection, cilium (By similarity). Cytoplasm (By similarity). Secreted (By similarity). Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. 

Tissue Specificity:
Expressed at high levels in testis, ovaries, thyroid, and spinal chord.

Similarity:
Belongs to the TUB family.

Database links:
Entrez Gene: 7289 Human
Omim: 604730 Human
SwissProt: O75386 Human
Unigene: 655333 Human


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

小鼠盆腔基因的突变逐渐导致肥胖,与人类人群中观察到的迟发性肥胖非常相似。除了脂肪组织的过度沉积外,具有盆腔表型的小鼠也遭受视网膜变性和神经感觉性听力损失。已经鉴定了TUB基因的人类同源物,有三种相关蛋白,称为TuBBY样蛋白1(Tulp1)、Tulp2和Tulp3。与TULP1和TULP2相比,TULP3具有更广泛的组织表达,并且在系统学上与TULP1或TULP2更相似。TULP1,特别是在视网膜中表达,映射到已知的视网膜色素变性的染色体区域,而TULP2映射在杆锥营养不良的最小间隔内。TULP3映射到人类染色体12p13,并与小鼠TULP3共享69%同源性。来自睾丸、卵巢、甲状腺和脊髓的人类RNA含有高度可检测水平的Tulp3转录本。在视网膜中,TULP3在内核层和神经节细胞层中特异表达。TULP1、TULP2和TULP3可以包括一个独特的二分转录因子家族。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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