FITC标记的TBR1蛋白抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的TBR1蛋白抗体
英文名称: Anti-TBR1/FITC
抗体货号: HZ-11603R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/13 15:26:00
详细资料:  实验方法技术资料
浏览人数:4
诚信指数:754点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
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电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-TBR1/FITC Conjugated antibody

FITC标记的TBR1蛋白抗体

 

产品编号 bs-11603R-FITC
英文名称 Anti-TBR1/FITC
中文名称 FITC标记的TBR1蛋白抗体
别    名 A novel murine and human gene, TBR-1, encodes a putative transcription factor related to the Brachyrury (T) gene that is expressed only in postmitotic cells. T-brain-1 (TBR-1) mRNA is largely restricted to the cerebral cortex, where, during embryogenesis, it defines different regions that give rise to the palecortex, limbic cortex and neocortex (1-3). TBR-1, Pax-6 and Emx-1 are expressed in the mouse and chicken pallium. The pallio-subpallial boundary lies at the interface between the TBR-1 and Dlx-2 expression domains. Chicken genes homolgous to these mouse genes are expressed in topologically comparable patterns during development, suggesting that mouse and chicken may have similar histogenetic specification processes and field homologies (4). CASK/LIN-2, a membrane-associated guanylate kinase, is required for EGFR localization and signaling. In adult rat brain, CASK is concentrated at neuronal synapses and binds to the cell-surface proteins. CASK can interact with TBR-1, which is involved in forebrain development. CASK enters into the nucleus and binds to a specific DNA sequence (the T-element) in a complex with TBR-1. Thus, CASK acts as a coactivator of TBR-1 to induce transcription of T-element containing genes, including reelin (5); TBR1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 74kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TBR1 (35-130aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
A novel murine and human gene, TBR-1, encodes a putative transcription factor related to the Brachyrury (T) gene that is expressed only in postmitotic cells. T-brain-1 (TBR-1) mRNA is largely restricted to the cerebral cortex, where, during embryogenesis, it defines different regions that give rise to the palecortex, limbic cortex and neocortex (1-3). TBR-1, Pax-6 and Emx-1 are expressed in the mouse and chicken pallium. The pallio-subpallial boundary lies at the interface between the TBR-1 and Dlx-2 expression domains. Chicken genes homolgous to these mouse genes are expressed in topologically comparable patterns during development, suggesting that mouse and chicken may have similar histogenetic specification processes and field homologies (4). CASK/LIN-2, a membrane-associated guanylate kinase, is required for EGFR localization and signaling. In adult rat brain, CASK is concentrated at neuronal synapses and binds to the cell-surface proteins. CASK can interact with TBR-1, which is involved in forebrain development. CASK enters into the nucleus and binds to a specific DNA sequence (the T-element) in a complex with TBR-1. Thus, CASK acts as a coactivator of TBR-1 to induce transcription of T-element containing genes, including reelin (5).

Function:
Probable transcriptional regulator involved in developmental processes. TBR1 is required for normal brain development.

Subcellular Location:
Nuclea 

Tissue Specificity:
Brain.

Similarity:
Contains 1 T-box DNA-binding domain.

Database links:
UniProtKB/Swiss-Prot: Q16650.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
   

新的小鼠和人类的基因,在全钢载重子午线- 1转录因子,encodes putative brachyrury(t)相关的基因的表达在有丝分裂后细胞是唯一的。的T - 1(R - 1)mRNA的表达在大脑皮质的主要限制是,它定义了在那里,embryogenesis,不同地区palecortex奋起,给了他的大脑皮层,皮质和中脑(1 - 3)。全钢载重子午线- 1 - 1和EMX Pax-6的表达在小鼠和鸡pallium。在pallio - subpallial谎言之间的界面边界在全钢载重子午线- 1和的DLx - 2的表达域。鸡基因的小鼠同源基因的表达在这些拓扑类似的模式是在发展,这提示可能有类似的小鼠和鸡的同源性的组织流程和规范场(4)。cask /林- 2,膜相关鸟苷酸激酶,表皮生长因子受体(EGFR)是必需的适当的定位和信号转导通路。在成年大鼠脑的神经元,突触和cask是集中在binds细胞表面的蛋白质。cask互动与TBR的CAN - 1,这是一forebrain参与开发。cask德的核DNA序列与特异性和binds(t元)在复杂的与R - 1。因此,cask行为的共激活因子1(TBR)的含氧基因转录的T -元素,包括reelin(5)。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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