FITC标记的转录因子OTX1+OTX2抗体
产品名称： FITC标记的转录因子OTX1+OTX2抗体
英文名称： Anti-OTX1 + OTX2/FITC
产品编号： HZ-11958R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-OTX1 + OTX2/FITC Conjugated antibody
FITC标记的转录因子OTX1+OTX2抗体
| 产品编号 | bs-11958R-FITC |
| 英文名称 | Anti-OTX1 + OTX2/FITC |
| 中文名称 | FITC标记的转录因子OTX1+OTX2抗体 |
| 别 名 | FLJ38361; Homeobox protein OTX 1; Homeobox protein OTX1; Homeobox protein OTX2; MCOPS 5; MCOPS5; MGC15736; MGC45000; Orthodenticle 1; Orthodenticle 2; Orthodenticle homeobox 1; Orthodenticle homeobox 2; Orthodenticle homolog 1; Orthodenticle homolog 2 (Drosophila); Orthodenticle homolog 2; Orthodenticle1; Orthodenticle2; Otx 1; Otx 2; otx1; OTX1_HUMAN; otx2; OTX2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 神经生物学 干细胞 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37/32kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human OTX1 + OTX2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q21-q22, respectively. Function: Function: Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. Subcellular Location: Nucleus Tissue Specificity: Expressed in brain. DISEASE: Defects in OTX2 are the cause of microphthalmia syndromic type 5 (MCOPS5) [MIM:610125]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Up to 80% of cases of microphthalia occur in association with syndromes that include non-ocular abnormalities. MCOPS5 patients manifest unilateral or bilateral microphthalmia/clinical anophthalmia and variable additional features including coloboma, microcornea, cataract, retinal dystrophy, hypoplasia or agenesis of the optic nerve, agenesis of the corpus callosum, developmental delay, joint laxity, hypotonia, and seizures. Similarity: Belongs to the paired homeobox family. Bicoid subfamily. Contains 1 homeobox DNA-binding domain. Database links: Entrez Gene: 5013 Human Entrez Gene: 5015 Human Entrez Gene: 18423 Mouse Entrez Gene: 30501 Zebrafish SwissProt: P32242 Human SwissProt: P32243 Human SwissProt: P80205 Mouse SwissProt: P80206 Mouse SwissProt: Q91981 Zebrafish Unigene: 288655 Human Unigene: 445340 Human Unigene: 129663 Mouse Unigene: 134516 Mouse Unigene: 334 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
转录因子OTX1和OTX2是果蝇原生质体（OTD）的两个鼠同源物，显示出有限的氨基酸序列差异。OTX1和OTX2在脑发育的早期和晚期所起的重要作用是参与大脑的诱导、规范和区域化的过程。OTX1参与皮质发育、感觉器官发育和垂体功能，而OTX2在发育早期是必需的，用于正确的前神经板规范和组织原始条纹。OTX2还需要在神经外胚层的早期规范中，这是注定要成为前中脑的，并且OTX1和OTX2协同通过剂量依赖的机制在显影的大脑中图案化。依赖于OTX蛋白的精确阈值的分子机制对于正确定位峡部区域和前脑构图是必要的。编码OTX1和OTX2的基因分别定位于人类染色体2p13和14q21-q22。