FITC标记的DHX螺旋酶抗体
产品名称： FITC标记的DHX螺旋酶抗体
英文名称： Anti-DHX32/FITC
产品编号： HZ-6944R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DHX32/FITC Conjugated antibody
FITC标记的DHX螺旋酶抗体
| 产品编号 | bs-6944R-FITC |
| 英文名称 | Anti-DHX32/FITC |
| 中文名称 | FITC标记的DHX螺旋酶抗体 |
| 别 名 | Ddx32; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32; DEAD/H box 32; DEAD/H helicase like protein 1; DEAH (Asp-Glu-Ala-His) box polypeptide 32; DEAH box protein 32; DHLP1; DHX32; Helicase DDX32; HuDDX32; Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32; DHX32_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 84kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DHX32 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DEAD-box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure and ribosome/spliceosome assembly. Based on their distribution patterns, some members of this family may be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX32 is a 743 amino acid nuclear protein that localizes to the mitochondria and is a member of the DEAD box helicase family. Expressed in various tissues, DDX32 is up-regulated by ionomycin in T lymphocytes and down-regulated in acute lymphoblastic leukemia. Considered a novel RNA helicase, DDX32 may play an important role in the development of colorectal cancer and may be involved in regulating T-cell response to certain apoptotic stimuli. Function: DHX32 is a member of the family of the DEAD box proteins, a group of proteins that present the conserved motif Asp-Glu-Ala-Asp (DEAD). They have a role in RNA translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Subcellular Location: Nucleus. Mitochondrion. Tissue Specificity: Expressed in lymphoid tissues (at protein level). Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung, lymphoid tissues and blood leukocytes. Similarity: Belongs to the DEAD box helicase family. DEAH subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Database links: UniProtKB/Swiss-Prot: Q7L7V1.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
死盒蛋白，其特征在于保守的基序ASP-Glu ALA-ASP，是推测的RNA解旋酶，涉及多个细胞过程，包括修饰RNA二级结构和核糖体/剪接体组件。根据它们的分布模式，该家族的一些成员可能参与胚胎发生、精子发生和细胞生长和分裂。DDX32是定位于线粒体的743氨基酸核蛋白，是死盒解旋酶家族的成员。在各种组织中，DDX32在T淋巴细胞中被离子霉素上调，在急性淋巴细胞白血病中被下调。DDX32被认为是一种新的RNA解旋酶，它可能在结直肠癌的发生中起重要作用，并且可能参与调节T细胞对某些凋亡刺激的反应。